Use of neoadjuvant electrochemotherapy to treat a large metastatic lesion of the cheek in a patient with melanoma
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Use of neoadjuvant electrochemotherapy to treat a large metastatic lesion of the cheek in a patient with melanoma Journal of Translational Medicine 2012, 10:131
doi:10.1186/1479-5876-10-131
Nicola Mozzillo ([email protected]) Corrado Caracò ([email protected]) Stefano Mori ([email protected]) Gianluca Di Monta ([email protected]) Gerardo Botti ([email protected]) Paolo A Ascierto ([email protected]) Corradina Caracò ([email protected]) Luigi Aloj ([email protected])
ISSN Article type
1479-5876 Research
Submission date
1 March 2012
Acceptance date
11 May 2012
Publication date
22 June 2012
Article URL
http://www.translational-medicine.com/content/10/1/131
This peer-reviewed article was published immediately upon acceptance. It can be downloaded, printed and distributed freely for any purposes (see copyright notice below). Articles in JTM are listed in PubMed and archived at PubMed Central. For information about publishing your research in JTM or any BioMed Central journal, go to http://www.translational-medicine.com/authors/instructions/ For information about other BioMed Central publications go to http://www.biomedcentral.com/
© 2012 Mozzillo et al. ; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Use of neoadjuvant electrochemotherapy to treat a large metastatic lesion of the cheek in a patient with melanoma Nicola Mozzillo1 Email: [email protected] Corrado Caracò1 Email: [email protected] Stefano Mori1 Email: [email protected] Gianluca Di Monta1* * Corresponding author Email: [email protected] Gerardo Botti2 Email: [email protected] Paolo A Ascierto3 Email: [email protected] Corradina Caracò4 Email: [email protected] Luigi Aloj4 Email: [email protected] 1
Department of Surgery “Melanoma - Soft Tissues - Head & Neck - Skin Cancers”, National Cancer Institute, Via Mariano Semmola, Naples, Italy 2
Department of Pathology, National Cancer Institute, Via Mariano Semmola, Naples, Italy 3
Medical Oncology and Innovative Therapies Unit, National Cancer Institute, Via Mariano Semmola, Naples, Italy 4
Department of Nuclear Medicine, National Cancer Institute, Via Mariano Semmola, Naples, Italy
Abstract Background Approximately 200,000 new cases of melanoma are diagnosed worldwide each year. Skin metastases are a frequent event, occurring in 18.2% of cases. This can be distressing for the patient, as the number and size of cutaneous lesions increases, often worsened by ulceration, bleeding and pain. Electrochemotherapy (ECT) is a local modality for the treatment of cutaneous or subcutaneous tumors that allows delivery of low- and non-permeant drugs into cells. ECT has been used in palliative management of metastatic melanoma to improve patient
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