Use of spectral tracking technique to evaluate the changes in left ventricular function in patients undergoing chemother
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ORIGINAL PAPER
Use of spectral tracking technique to evaluate the changes in left ventricular function in patients undergoing chemotherapy for colorectal cancer Zhen Wang1 · Wenjuan Qin1 · Zijing Zhai1 · Lei Huang1 · Jia Feng1 · Xueting Guo1 · Kuican Liu1 · Caiyun Zhang1 · Zhong Wang2 · Guilin Lu1 · Shanshan Dong1 Received: 7 August 2020 / Accepted: 8 November 2020 © Springer Nature B.V. 2020
Abstract To evaluate the changes in left ventricular myocardial function in patients with colorectal cancer undergoing chemotherapy with mFOLFOX6 (oxaliplatin + 5-fluorouracil + calcium folinate) using three-dimensional speckle-tracking echocardiography (3D-STE). Data were collected from 30 patients diagnosed with colorectal cancer in our hospital treated with mFOLFOX6. We used 3D-STE to measure the following parameters of left ventricle function: global longitudinal strain (GLS), global area strain (GAS), global circumferential strain (GCS), global radial strain (GRS), and left ventricular twist (LVtw). Myocardial composite index (MCI) was calculated from measured values (MCI = GLS × LVtw). The above listed parameters were compared before and after chemotherapy. Receiver operating curves (ROC) were prepared for each parameter and analyzed to identify correlations among MCI, LVEF, GLS, and cTnT. Compared with the pre-chemotherapy state, the absolute values of MCI, LVtw, GLS, GAS, GCS, and GRS decreased with increasing cumulative doses of chemotherapeutic drugs. The absolute values of GAS, GLS, MCI, and LVtw decreased after the first cycle of chemotherapy (P 14 pg/mL considered abnormal. After blood sample collection, participants underwent an echocardiographic examination. The initial images were collected by echocardiography technicians with more than 10 years of experience. Electrocardiogram leads were connected and the participant was positioned lying on the left side. Echocardiography images were acquired using M5S probe (60–80 frames/s). M-mode echocardiography was used to measure and record the following values from the long-axis images of the left ventricle, measured next to the sternum: left ventricular short axis shortening fraction (LVFS), left ventricular end-diastolic diameter (LVEDd), interventricular septum end-diastolic thickness (IVSd), and left ventricular posterior wall end-diastolic thickness (LVPWd). Left ventricular ejection fraction (LVEF) was measured using a modified Simpson method. The early diastolic peak velocity (E) of the mitral orifice and the early diastolic peak velocity (e′) of the tissue Doppler mitral annulus were measured on the four-chamber
cutting surface of the apex, and the E/e′ value was obtained. And we used E/e′ to assess diastolic function in all patients. We subsequently used the 4 V probe in the 4D mode, adjusting the frame rate to 40% of the participant’s maximal heart rate. Participants were instructed to hold their breath at the end of expiration and images acquired. We collected dynamic images of the left ventricular apical four-chamber view (at least 5 cardiac cycles), wh
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