• PDF / 141,973 Bytes
• 1 Pages / 595.245 x 841.846 pts (A4) Page_size
• 35 Downloads / 127 Views

DOWNLOAD

REPORT

---

1

S

Neutropenia in renal transplant recipients: 2 case reports Two renal transplant recipients developed neutropenia after treatment with valaciclovir and valganciclovir [route, therapeutic indication and duration of treatment to reaction onset not stated]. Patient 1 was an 18-year-old adolescent male who developed fatigue and loss of appetite 2 months after a renal transplant. His medications included mycophenolate mofetil, ciclosporin and valganciclovir 900 mg/day. Laboratory investigations revealed a leukocyte count of 1.7 × 109/L. Discontinuation of mycophenolate mofetil and valganciclovir failed to improve his neutrophil count, which did not rise above 0.1 × 109/L, so he was treated with a granulocyte colony-stimulating factor. In 24 hours, his leukocyte count improved to 6.5 × 109/L and his neutrophils increased to 2.2 × 109/L. Patient 2, was a 37-year-old man who developed fatigue and burning sensations in his stomach 3 months following a renal transplant. His medications inlcuded mycophenolic acid, tacrolimus, and valaciclovir 4.5 g/day. Laboratory investigations revealed a leukocyte count of 1.3 × 109/L. His leukoopenia persisted despite mycophenolic acid and valaciclovir discontinuation; his leukocyte and neutrophil counts failed to rise above 1.4 × 109/L and 0.1 × 109/L, respectively. He received a granulocyte colony-stimulating factor, and after his third dose, his neutrophils increased to 3.8 × 109/L and his leukocytes to 5.8 × 109/L. Author comment: "In our patients, neutropenia was related to the use of valacyclovir and valganciclovir; there was no evidence of an infection, and granulocyte colony stimulating factor was used to treat persistent neutropenia, despite discontinuation of antiviral agents." Keles M, et al. Neutropenia related to valacyclovir and valganciclovir in 2 renal transplant patients and treatment with granulocyte colony stimulating factor: A case report. Experimental and Clinical Transplantation 8: No. 2, Jun 2010 803036856 Turkey

0114-9954/10/1318-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved

Reactions 11 Sep 2010 No. 1318