Vascular aging long-term effect of cisplatin-based chemotherapy
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Vascular aging long-term effect of cisplatin-based chemotherapy Long-term survivors of testicular cancer (TC) show increased vascular damage more than 20 years after treatment with cisplatin-based chemotherapy, according to a study from the Netherlands. The study assessed the presence of vascular damage in patients with TC surviving > 20 years after treatment with orchiectomy followed by cisplatin-based chemotherapy or orchiectomy only, compared with age-matched controls. Assessments included carotid-femoral pulse wave velocity (cf-PWV) as a measure of arterial stiffness, presence of Raynaud’s phenomenon and vascular biomarkers. The analysis of data from 127 TC survivors, with a median follow-up duration of 28 years, and 70 age-matched controls showed that TC survivors had significantly higher cf-PWV than controls (8.07 vs 7.58 m/s). Furthermore, TC survivors who had received chemotherapy (n = 70) had significantly higher cf-PWV than TC survivors who had undergone orchiectomy only (8.46 vs 7.61 m/s). Multivariate regression analysis revealed that chemotherapy was a significant independent predictor for increased cf-PWV. These "findings on vascular stiffness support the notion of accelerated vascular aging after [chemotherapy] in TC survivors," comment the researchers. Furthermore, the number of patients who reported clinically significant symptoms of Raynaud’s phenomenon was significantly higher among TC survivors than in controls (29% vs 11%), and significantly higher in chemotherapy recipients than in the orchiectomyonly group (41% vs 16%). Digital cooling tests showed longer ischaemic times in chemotherapy recipients. In addition, albuminuria occurred more often in TC survivors. Stelwagen J, et al. Vascular aging in long-term survivors of testicular cancer more than 20 years after treatment with cisplatin-based chemotherapy. British Journal of Cancer : 803503738 14 Sep 2020. Available from: URL: http://doi.org/10.1038/s41416-020-01049-3
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Reactions 26 Sep 2020 No. 1823
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