V(D)J Recombination
v(D)J recombination: for the community of immunologists and developmental biologists, the molecular route by which B and T lymphocytes acquire their unique function of affording adaptive immunity. Yet, for many-from experienced scientists to trainees-it r
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ADVANCES IN EXPERIMENTAL MEDICINE ANDBIOLOGY Editorial Board: NATHAN BACK,State University ofNew York at Buffalo IRUNR. COHEN, The Weizmann Institute ofScience ABELLAJTHA, N.S. KlineInstitutefor PsychiatricResearch JOHND. LAMBRIS, University ofPennsylvania RODOLFO PAOLETfI, UniversityofMilan RecentVolumes in this Series Volume 642 THE SARCOMERE AND SKELETAL MUSCLE DISEASE Editedby NigelG. Laing Volume 643 TAURINE 7 Editedby JunichiAzuma Volume 644 TROPOMYOSIN Editedby PeterGunning Volume 645 OXYGEN TRANSPORT TOTISSUE XXX Editedby Per Liss, PeterHansell, DuaneF. Bruley, and DavidK. Harrison Volume 646 EARLY NUTRITION PROGRAMMING ANDHEALTH OUTCOMES IN LATER LIFE Editedby Berthold Koletzko, Tamas Desci,DenesMolnar, andAnneDe la Hunty Volume 647 THERAPEUTIC TARGETS OFTHETNF SUPERFAMILY Editedby IqbalGrewal Volume 648 ARTERIAL ANDALLIED CHEMORECEPTORS Editedby Constancio Gonzalez, ColinA. Nurse, and ChrisPeers Volume 649 MOLECULAR MECHANISMS OF SPONDYLOARTHROPATHIES Editedby CarlosLopez-Larrea, and RobertoDlaz-Pena Volume 650 V(D)JRECOMBINATION Editedby PierreFerrier A Continuation Order Plan is available for this series. A continuation orderwill bring delivery of each new volume immediately upon publication. Volumes arebilled onlyupon actual shipment. Forfurther information please contact thepublisher.
V(D)J Recombination Edited by
Pierre Ferrier, MD, PhD Centre d'Immunologie de Marseille-Luminy, Universite d'Aix Marseille, Marseille, France
Springer Science+Business Media, LLC Landes Bioscience
Springer Science+Business Media, LLC Landes Bioscience Copyright ©2009 Landes Bioscience and Springer Science+Business Media, LLC All rightsreserved. Nopartof thisbookmaybereproduced ortransmittedin anyformorbyanymeans, electronic ormechanical, including photocopy, recording, or anyinformation storageandretrieval system, without permission in writing from the publisher, withthe exception of any material supplied specifically forthe purpose of beingenteredand executed on a computer system; for exclusive use by the Purchaser of the work. Printedin the USA. Springer Science+Business Media, LLC, 233 Spring Street, NewYork, NewYork 10013, USA http://www.springer.com Pleaseaddress all inquiries to the publishers: LandesBioscience, 1002 WestAvenue, Austin, Texas 78701,USA Phone: 51216376050;FAX: 512/637 6079 http://www.landesbioscience.com The chapters in this bookare available in the Madame CurieBioscience Database. http://www.landesbioscience.comlcurie V(D)JRecomination, editedby PierreFerrier. LandesBioscience 1Springer Science+Business Media, LLCdual imprint 1Springer series: Advances in Experimental Medicine and Biology. ISBN: 978-1-4419-0295-5 Whiletheauthors, editors andpublisher believethatdrugselection anddosageandthespecifications and usage of equipment and devices, as set forth in this book,are in accordwith currentrecommendations and practice at the time of publication, they makeno warranty, expressed or implied, with respect to material described in this book. In view of the ongoing research, equipment development,
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