Viral Genome Replication
Currently, there is no single source that permits comparison of the factors, elements, enzymes and/or mechanisms employed by different classes of viruses for genome replication. As a result, we (and our students) often restrict our focus to our particular
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Craig E. Cameron · Matthias G¨otte · Kevin D. Raney Editors
Viral Genome Replication
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Editors Craig E. Cameron Pennsylvania State University University Park PA, USA [email protected]
Matthias G¨otte McGill University Montreal, Quebec Canada [email protected]
Kevin D. Raney University of Arkansas for Medical Sciences Little Rock, AR USA [email protected]
ISBN 978-0-387-89425-6 DOI 10.1007/b135974
e-ISBN 978-0-387-89456-0
Library of Congress Control Number: 2009920268 c Springer Science+Business Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper springer.com
Preface
Currently, there is no single source that permits comparison of the factors, elements, enzymes and/or mechanisms employed by different classes of viruses for genome replication. As a result, we (and our students) often restrict our focus to our particular system, missing out on the opportunity to define unifying themes in viral genome replication or benefit from the advances in other systems. For example, extraordinary biological and experimental paradigms that have been established over the past 5 years for the DNA replication systems of bacteriophage T4 will likely be of great value to anyone interested in studying a replisome from any virus. These studies could easily go unnoticed by animal RNA and DNA virologists. It is our hope that this monograph will cross-fertilize and invigorate the field, as well as encourage students into this area of research. The monograph has been divided into eight parts. Chapters appearing in Parts I–VI are intended to compare and contrast the replication and/or transcription processes and corresponding “players” of the indicated family of viruses. We are interested in the sequence of events that lead to production of mRNA and progeny genomes as well as the cis-acting elements and trans-acting factors and enzymes (viral and cellular) that are required for these processes. Chapters appearing in Part VII are intended to provide a more biochemical and b
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