Viscoelastic properties of clot formation and their clinical impact in East Asian versus Caucasian patients with stable
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Viscoelastic properties of clot formation and their clinical impact in East Asian versus Caucasian patients with stable coronary artery disease: a COMPARE‑RACE analysis Young‑Hoon Jeong1,2 · Bliden Kevin3 · Jong‑Hwa Ahn1 · Rahul Chaudhary3 · Min Gyu Kang2 · Hyun Woong Park2 · Jin‑Sin Koh4 · Yongwhi Park1,2 · Udaya S. Tantry3 · Paul A. Gurbel3
© Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Compared with Caucasian patients, East Asian patients with coronary artery disease (CAD) have demonstrated better clinical outcomes. We sought to compare the viscoelastic properties of clot formation and their impact on clinical outcomes in East Asian vs. Caucasian patients. We analyzed age- and sex-matched East Asian and Caucasian patients with stable CAD (n = 249 each). Viscoelastic properties of clot formation were assessed with thromboelastography (TEG), and 3-year clinical outcomes were recorded. Major adverse cardiovascular events (MACE) were defined as a composite of cardiovascular death, myocardial infarction, or stroke. Compared with Caucasians, East Asians showed lower platelet–fibrin clot strength (PFCS) (maximum amplitude [MA]: 61.8 ± 7.9 vs. 65.4 ± 5.0 mm, p
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