Visualization of flow in the ascending aorta: bicuspid aortic valves compared to tricuspid aortic valves
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Visualization of flow in the ascending aorta: bicuspid aortic valves compared to tricuspid aortic valves Christian Meierhofer1*, Christine Lyko1, Eike Philipp Schneider1, Andrea Hutter1, Heiko Stern1, Stefan Martinoff1, Alfred Hager1, John Hess1, Michael Markl2, Sohrab Fratz1 From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Study’s objective The aim of this prospective matched-pair study was to compare different 3D flow patterns in the ascending aorta caused by native bicuspid aortic valves (BAV) compared to tricuspid aortic valves (TAV). Background The presence of bicuspid aortic valves may account for dilation of the ascending aorta and increase morbidity and mortality in this patient group. There is an ongoing debate on the cause of increasing diameters of the ascending aorta. Intrinsic wall abnormalities due to genetic development have been discussed as well as altered hemodynamic properties due to different valve patterns. Methods Our prospective matched-pair study included 18 patients (median age 25 years, range 8 - 44 years) with a native bicuspid aortic valve and normal diameters of the ascending aorta, without stenosis or insufficiency of the aortic valve and no coarctation of the aorta. All of the 18 patients were age- and sex- matched with 18 controls with a tricuspid aortic valve. All patients with BAV were otherwise healthy without any cardiovascular disease. Both groups underwent time-resolved flow-sensitive 4D CMR for the individual evaluation of 3D flow pattern of the ascending aorta (spatial resolution = 2.1 x 1.7 x 2.5 mm3, temporal resolution = 39.2 ms). All data sets were evaluated independently by three blinded 1 German Heart Center Munich, Munich, Germany Full list of author information is available at the end of the article
investigators. According to a predefined classification, the helical flow patterns were graded.
Results The blinded evaluation resulted in 90% in correct classification of BAV or TAV. In the BAV group, 85 % showed a flow pattern with a high-grade helix formation in the ascending aorta. The matched pairs showed a statistically significant difference of the flow patterns. Figure 1. Conclusions In about 90 % the aortic valve morphology BAV or TAV can be accurately predicted by the individual flow pattern measured by 4D CMR. Without concomitant lesions and normal aortic dimensions most of the patients with BAV show a pathologic flow pattern. We suggest that this method may help to distinguish patients with BAV at risk for aortic dilatation.
Figure 1 Matched pair (left BAV, right TAV) of 32-year old women.
© 2011 Meierhofer et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Meierhofer et al. Journal of Cardiovascular Magnetic Resonance 2011, 13(Suppl 1)
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