Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies
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RESEARCH
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Vitamin D receptor Bsm I polymorphism and osteoporosis risk in postmenopausal women: a meta-analysis from 42 studies Jun Long Liao1†, Qiang Qin2†, Yong Sheng Zhou1, Ru Ping Ma1, He Chao Zhou1, Mao Rong Gu1, Yun Ping Feng1, Bo Yuan Wang3* and Ling Yang1*
Abstract Objective: This study aimed to quantitatively summarize the evidence for VDR BsmI gene polymorphism and osteoporosis risk in postmenopausal women. Materials and methods: The PubMed, EMBASE, Weipu, CNKI, and Wanfang databases were searched for eligible studies. Case-control studies containing available genotype frequencies of B/b were chosen, and odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. Results: 4485 osteoporosis and 5490 controls were identified in our meta-analysis. In the stratified analysis, a significant association was observed between VDR BsmI gene polymorphism and osteoporosis susceptibility in Caucasians (additive model: OR = 0.809, 95% CI 0.678~0.965, p = 0.019; recessive model: OR = 0.736, 95% CI 0.568~0.955, p = 0.021; and co-dominant model: bb vs. BB OR = 0.701, 95% CI 0.511~0.962 p = 0.028), and we failed to find any significant relationship in Asians. Conclusion: The present meta-analysis suggests that VDR BsmI genotype is associated with increased risk of postmenopausal osteoporosis in Caucasians but not in Asians. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between VDR BsmI polymorphism and osteoporosis in postmenopausal women. Keywords: Vitamin D receptor, BsmI polymorphism, Osteoporosis, Postmenopausal, Meta-analysis
Introduction Osteoporosis, as a systemic bone disease characterized by decreased bone mineral density, micro-structure deterioration of bone tissue, and increased risk of bone fracture [1, 2], is commonly seen in postmenopausal females and aged males; about 30% of postmenopausal females suffer from osteoporosis [3]. Bone fractures caused by osteoporosis are extremely harmful and are one of the main causes * Correspondence: [email protected]; [email protected] † Junlong Liao and Qiang Qin contributed equally to this work. 3 The Key Lab of Sports and Rehabilitation, Faculty of Physical Education, Yuxi Normal University, Yuxi 653100, China 1 The People’s Hospital of Yuxi City, The 6th Affiliated Hospital of Kunming Medical University, Yuxi 653100, China Full list of author information is available at the end of the article
of disability and death in elderly patients. Research on early identification of high-risk groups has been carried out, which is of substantial clinical significance. The pathogenesis of osteoporosis is currently unclear. It is widely accredited that osteoporosis is related to individual genetic differences, estrogen levels, nutritional status, and lifestyle. In addition, osteoporosis can also be induced by bone formation and bone resorption disorder caused by physical injury, diseases affecting bone metabolism, or lo
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