Volume Replacement

Because of their therapeutic safety, hydroxyethylstarch, gelatin and dextrans are among the most frequently used drugs in the world. Recent studies have shown that bleeding disorders, anaphylactic reactions and storage in the body depend decisively on the

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Springer Berlin Heidelberg New York Barcelona Budapest Hong Kong London Milan Paris Santa Clara Singapore Tokyo

J.-F.

BARON

J.

TREIB

(Eds.)

Voume Re acement Mit 23 Abbildungen

Springer

Professor Dr. med. JEAN-FRA"NCOIS BARON Universite Pierre et Marie Curie Paris VI Anesthesie-Reanimation 96, rue Didot 75014 Paris, France Priv.-Doz. Dr. med. JOHANNES TREIB Universitatskliniken des Saarlandes Neurologische Klinik KirrbergerstraBe 66421 Homburg/Saar, Germany

ISBN-13: 978-3-540-64187-2 DOl: 10.1007/978-3-642-72170-0

e-ISBN-13: 978-3-642-72170-0

CIP Data applied for Die Deutsche Bibliothek - CIP-Einheitsaufnahme Volume replacement 1 J.-F. Baron, J. Treib (ed.). - Berlin; Heidelberg; New York; Barcelona; Budapest; Hong Kong; London; Milan; Paris; Santa Clara; Singapore; Tokyo: Springer, 1998 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consnlting the relevant literature. ©

Springer-Verlag Berlin Heidelberg 1998

The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Typesetting: K+V Fotosatz GmbH, Beerfelden Cover-design: D & P, Heidelberg SPIN 10652825

18/3137-5

4 3 2 1 0 - Printed on acid-free paper

Preface

Since the 1980s, the clinical practice of plasma volume expansion has changed considerably: fresh frozen plasma has been replaced by colloids. At the beginning of the 1990s, the administration of serum albumin was the most common means of plasma volume expansion, but it was misused in many clinical situations. Because albumin is sometimes in short supply and is currently more costly than artificial colloids, control of its overuse has significant clinical and economic ramifications for hospitals. In an effort to optimize the use of albumin, several societies of anesthesiologists and intensive care physicians have developed guidelines based on the currently available literature, demonstrating therapeutic equivalence between artificial colloids and albumin in many clinical situations. The impact of these guidelines has been a subject of debate since observational studies were conducted to characterize the use of albumin and artificial colloids and to dete