Vonoprazan
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Anaphylactic shock: case report A woman in her 30s developed anaphylactic shock during treatment with vonoprazan for reflux oesophagitis. The woman had heartburn for a few weeks. Based on findings of gastroscope performed at another hospital she was diagnosed with reflux oesophagitis. Therefore, she had started receiving vonoprazan [vonoprazan fumarate; Takecab] tablet 20 mg/day, to be taken before bed. Three hours after taking first dose of vonoprazan, she developed pruritus and nausea, and visited the emergency department. Owing to generalised flushing, decreased BP and percutaneous oxygen saturation (SPO2) of 98%, anaphylactic shock was assumed. The woman was treated with epinephrine [adrenaline]. She was admitted to the hospital. Vonoprazan was discontinued with the dosing on the previous day (first dose). She was treated with methylprednisolone for 2 days. Erythema was observed on the thighs. Generalised itching persisted. Three days after the discontinuation of vonoprazan, her symptoms were resolving. She was discharged from the hospital. Later, drug-induced lymphocyte stimulation test (DLST) was performed, which gave positive results for vonoprazan. PMDA - Pharmaceuticals and Medical Devices Agency. Vonoprazan fumarate Pharmaceuticals and Medical Devices Safety Information 377: 21-22, 10 Nov 2020. Available 803515678 from: URL: https://www.pmda.go.jp/files/000237389.pdf
0114-9954/20/1831-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
Reactions 21 Nov 2020 No. 1831
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