VUV-photon Induced Formation of Hydrophilic and Hydrophobic Micro Domains Structure on Intraocular Lens Surface for Bloc
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re1. Experimental setup for photochemical surface modification for silicone rubber.
abs. coeffi. of amide band
0.008 water
0.007
formic acid
ammonia
0.006 0.005 0.004 0.003 0.002 0.001 0
15
35
55
75
95
115
contact angle [degree] Figure 3. Comparison with several functional group incorporation and fibrin adsorption on silicone rubber.
Formation of hydrophilic and hydrophobic micro-domain structure Based on the result in Figure 3, the water was employed as the reaction solution for formation of hydrophilic-hydrophobic micro domain structure. Figure 4 illustrated the experimental setup for micro-domain structure. Water is poured on the silicone IOL surface, and a fused silica glass is placed on top of it to produce a thin film by capillary phenomenon. The ArF excimer laser is then projected through a 50 micrometer patterned reticle. With this treatment, the part selectively exposed is modified to be hydrophilic. As a result, the micro-domains structure consisting of hydrophilic and hydrophobic groups arranged alternatively is photo-chemically created on the silicone IOL, as shown in Figure 4
Figure 4. Hydrophilic and hydrophobic micro-domain structure making on silicone intraocular lens surface The hydrophilic group was incorporated at interval of 50 micrometer on the silicone IOL surface. The contact angle on the untreated silicone IOL was 120 degrees. The contract angle reached to 82 degrees at laser fluence of 25mJ/cm2 and laser shot number of 10000. Because it
revealed that the area ratio of hydrophilic and hydrophobic is 1 to 3. Furthermore, the fibrinsticking test was carried out on the micro-domain silicone surface. It results that the absorption coefficient of the amide band became 0.0006, decreasing to one-six of the non-treatment sample’s.
CONCLUSIONS The –OH or –COOH or –NH2 groups were photo-chemically incorporated on the silicone IOL surface by VUV photon irradiation. As the results, it was found that the modified sample with water is best for the affinity to the fibrin. Furthermore, the hydrophilic and hydrophobic micro-domain structure was inhibited the fibrin sticking. The results indicated that this material could be used for an IOL that inhibits after cataract.
ACKNOWLEDGMENTS This research was supported in part by grant #19659446 from the Ministry of Education and science JAPAN.
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