What About Gastric Schwannoma? A Review Article
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REVIEW ARTICLE
What About Gastric Schwannoma? A Review Article Sara Lauricella 1 & Sergio Valeri 2 & Gianluca MascianĂ 1 & Ida Francesca Gallo 2 & Erica Mazzotta 1 & Chiara Pagnoni 1 & Saponaro Costanza 1 & Lorenza Falcone 3 & Domenico Benvenuto 4 & Marco Caricato 1 & Gabriella Teresa Capolupo 1
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose Gastric schwannomas (GSs) are rare mesenchymal neoplasms of the gastrointestinal tract. Diagnosis is often achieved postoperatively, based on pathology reports of retrieved specimens. The aim of the present study is to follow up all patients with gastric schwannoma (Gs) undergoing endoscopic, partial, or more extended surgery and to evaluate the appearance of local or distant recurrence. Methods A PubMed, Cochrane, and Embase systematic review of the literature has been performed. Original papers, review articles, and case reports published between 1988 and 2019 were considered eligible. All the studies who met the inclusion criteria were analyzed. Statistical analysis of data has been performed using GraphPad Prism 7 software. Results Three hundred twenty-eight articles were found, and a total of 102 were included and analyzed in depth. Fifty-three papers reported the follow-up information, ranging from 1 to 417 months across different studies. Among them, 31 patients underwent endoscopic removal of the gastric lesions; 140 patients underwent local surgery, including wedge resection or partial gastrectomy; and 148 patients underwent subtotal or total gastrectomy. The median follow-up was of 27-38-33 months, respectively. No recurrence or distant metastasis was detected in the endoscopy group. Among local surgery group, liver metastasis was reported in one case; in extended surgery group, one patient died for multiple liver metastases. Conclusions Local or more extended surgery involved a larger cohort of patients and reported satisfactory long-term results compared with endoscopy group. Surgery in absence of a definite preoperative diagnosis is considered the gold standard treatment for resectable Gs. Keywords Schwannoma . Neurinoma . Gastric neurinoma . Gastric schwannoma
Abbreviations Gs Gastric schwannoma GIs Gastrointestinal schwannomas GISTs Gastrointestinal stromal tumors SMTs Submucosal tumors
* Sara Lauricella [email protected] 1
Department of Colorectal Surgery, Campus Bio-Medico University, Rome, Italy
2
Department of Surgery for Soft Tissue Sarcoma, Campus Bio-Medico University, Rome, Italy
3
Department of Pathology, Campus Bio-Medico University, Rome, Italy
4
Unit of Medical Statistic and Epidemiology, Department of Medicine, Campus Bio-Medico University, Rome, Italy
EUS CT SMA E U S FNAB GFAP EFTR ESD EE-L
Endoscopic ultrasonography Computed tomography Smooth muscle actin Endoscopic ultrasound-guided fine-needle aspiration biopsy Glial fibrillary acid protein Full-thickness resection Endoscopic submucosal dissection Ligation-assisted endoscopic enucleation
Introduction Schwannomas, also known as neurile
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