Which Factors in Spinocerebellar Ataxia Type 3 Patients Are Associated with Restless Legs Syndrome/Willis-Ekbom Disease?
- PDF / 647,311 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 35 Downloads / 185 Views
ORIGINAL ARTICLE
Which Factors in Spinocerebellar Ataxia Type 3 Patients Are Associated with Restless Legs Syndrome/Willis-Ekbom Disease? Lívia Leite Góes Gitaí 1 & Alan Luiz Éckeli 2 & Manoel Alves Sobreira-Neto 3 & Paula Rejane Beserra Diniz 4 & Antônio Carlos Santos 4 & Wilson Marques Júnior 2 & Regina Maria França Fernandes 2
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract There is evidence of a higher prevalence of restless legs syndrome/Willis-Ekbom disease (RLS/WED) in individuals with spinocerebellar ataxia type 3 (SCA3), although the factors underlying this association remain unknown. The present study aimed to determine the prevalence of RLS/WED in SCA3 patients and to investigate which factors of SCA3 patients are associated with presence of RLS/WED. From February to August of 2006, we carried out clinical interviews in 40 controls and 40 SCA3 patients, diagnosed and followed up at Faculty of Medicine of Ribeirão Preto, University of São Paulo. Twenty-seven SCA3 patients were submitted to a detailed clinical protocol, electroneuromyography, blood work up, polysomnography (PSG), suggested immobilization test (SIT), and magnetic resonance image (MRI). RLS/WED was found in 27.5% of SCA3 patients and 2.5% of normal controls (p = 0.003). The factors related to RLS/WED in SCA3 patients were female gender, age at start of the symptoms of ataxia after 30 years, presence of peripheral neuropathy, and documented iron deficiency. Among SCA3 patients, those with RLS showed higher values of maximal discomfort level and discomfort level sum compared to non-RLS individuals on SIT. There is a relation between RLS/WED and SCA3, which seems to be resultant of different factors whose identification could improve the quality of assistance to those patients as well as to promote a better comprehension of the pathophysiology of both RLS/WED and SCA3. Keywords Restless legs syndrome . Willis-Ekbom disease . Spinocerebellar ataxias . Machado-Joseph disease . Magnetic resonance imaging . Suggested immobilization test
Introduction
* Lívia Leite Góes Gitaí [email protected] 1
Faculty of Medicine, Federal University of Alagoas, Campus Universitário. Avenida Lourival Melo Mota S/N. Tabuleiro dos Martins, Maceio, Alagoas 57072-900, Brazil
2
Department of Neuroscience, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Campus Universitário - Rua Bernardino de Campos, 1000 - Centro, Ribeirao Preto, SP 65470-000, Brazil
3
Department of Clinical Medicine, Faculty of Medicine, Federal University of Ceará, Rua Prof. Costa Mendes, 1408 – 4°. Andar, Fortaleza 60430-140, Brazil
4
Department of Radiology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Campus Universitário - Rua Bernardino de Campos, 1000 - Centro, Ribeirão Preto, SP 65470-000, Brazil
Restless legs syndrome/Willis-Ekbom disease (RLS/WED) is a sensorimotor disorder characterized by an urge to move the legs that begins or worsens during periods of rest; it is partially or totally relieved by movement
Data Loading...
