WHODrug: A Global, Validated and Updated Dictionary for Medicinal Information
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EDUCATIONAL REVIEW
WHODrug: A Global, Validated and Updated Dictionary for Medicinal Information Olof Lagerlund, PhD1 · Sara Strese, PhD1 · Malin Fladvad, PhD1 · Marie Lindquist, PhD1 Received: 23 December 2019 / Accepted: 9 February 2020 © The Author(s) 2020
Abstract The WHODrug medicinal information dictionary is a worldwide source of global medicinal information with the aim to facilitate the coding of medications in clinical trials as well as identification of medication-related problems when monitoring patient safety, thereby supporting the development and usage of effective and safe medications. WHODrug contains individual trade names, active ingredients and additional information such as marketing authorisation holder, country of sale, pharmaceutical form and strength. All related medications are linked using a structured WHODrug alphanumeric code, connecting trade names and variation of the ingredient with the active moiety of the ingredient. Medications in WHODrug are classified using the ATC system and clustered into Standardised Drug Groupings, to allow for grouping of medications with one or more properties in common. The built-in data structure and the classification of medications in WHODrug facilitate various ways of aggregating medications for identification and analysis of possible adverse drug reactions. The different information levels in WHODrug are used to explore the relationship between a medication or a class of medications and an adverse event. By using WHODrug in clinical trials and post-marketing safety, accurate and standardised medication information can be achieved globally and allow easy information exchange. To meet the demands of WHODrug users from the pharmaceutical industry, academia and regulatory authorities, it is relevant to keep the dictionary comprehensive, validated and constantly updated on a global scale. Keywords Pharmacovigilance · Clinical trial · Patient safety · Adverse event · Standardised Drug Groupings (SDG) · Drug coding
What is WHODrug? WHODrug is a global medicinal information dictionary that contains medicinal products and active ingredients intended for human use, such as active chemical substances, biotherapeutics, vaccines, dietary supplements, herbal remedies, radio pharmaceuticals and diagnostic agents. The information of the medications in WHODrug includes trade name, ingredient, pharmaceutical form, strength, country of sales and marketing authorisation holder (MAH). The development and maintenance of WHODrug is managed by Uppsala
Olof Lagerlund and Sara Strese shared first author. * Olof Lagerlund Olof.lagerlund@who‑umc.org 1
Uppsala Monitoring Centre, Box 1051, 751 40 Uppsala, Sweden
Monitoring Centre (UMC), the WHO Collaborating Centre for International Drug Monitoring. In order to meet the demands of its users and to keep WHODrug current and comprehensive, it is continuously updated and adapted to international standards. All medicinal information is verified in at least one reliable national or international reference or directly from m
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