Wound Healing and Skin Physiology
On the occasion of the European Congress on Wound Healing and Skin Physiology (Bochum, Germany, November 1992), an international team of scientists and clinicians discussed the core topics in this important field of dermatological and surgical research. T
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(Eds.)
Wound Healing and Skin Physiology
With 276 Figures and 56 Tables
Springer-Verlag Berlin Heidelberg New Yark London Paris Tokyo Hong Kong Barcelona Budapest
Prof. Dr. PETER ALTMEYER Dr. KLAUS HOFFMANN Dr. STEPHAN EL GAMMAL Ruhr-U niversitat Dermatologische Klinik im St. Josef-Hospital Gudrunstr. 56 44791 Bochum Germany Dr. JERRY HUTCHINSON ConvaTec Wound Healing Institute Deeside, Clwyd CH5 2NU U.K.
ISBN-13: 978-3-540-56124-8 e-ISBN-13: 978-3-642-77882-7 DOT: 10.1007/978-3-642-77882-7 CIP data applied for This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law.
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Contents
I. History of Wound Healing
Theory and Practice of Wound Healing in the Past I. Muller . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
3
De rara medicatione vulnerum: An Historical Approach to Wound Care N.N. Aldini, M. Fini, G. Giavaresi, and R. Giardino. . . . . .
19
II. Morphology and Physiology
Fetal Wound Repair I.K. Cohen and J.H. Haynes. . . . . .... . . . ........... . . ..
27
Histological Examination of Skin Grafts A. Fisseler-Eckhoff and K.-M. Muller. . . . . . . . . . . . . . . . . . .
33
Reepithelialisation of Wounds I.M. Leigh ..........................................
45
Pathophysiology of Wound Healing in Venous Leg Ulcers J.R. Mekkes and W. Westerhof ................ , . ... . . .
61
Collagen Metabolism and Wound Contraction G. Abatangelo, P. Hrun, and R. Cortivo ......... , . . ... . .
71
The Role of the Connective Tissue Matrix in Wound Healing: Fibroblast and Collagen Interactions H.P. Ehrlich. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
89
Modulation of Fibroblastic Cytoskeletal Features During Wound Healing and Fibrosis A. Desmouliere and G. Gabbiani... . . . .... . . . . . .. . . ....
105
VI
Contents
III. Microcirculation and Angiogenesis
