Younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of pre
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(2020) 20:410
RESEARCH ARTICLE
Open Access
Younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature atherosclerosis Michał Ambroziak* , Katarzyna Niewczas-Wieprzowska, Agnieszka Maicka and Andrzej Budaj
Abstract Background: Premature coronary artery disease is one of the most pressing global issues in modern cardiology. The aim of the study was to investigate the role of family history of premature cardiovascular disease (CVD) in patients aged < 50 years with myocardial infarction (MI) compared to that in patients aged ≥50 years with MI and to that in young people without MI (no-MI < 50). Methods: The studied group (MI < 50) consisted of 240 patients aged 26–49 years with MI. The control groups consisted of 240 patients (MI ≥ 50) with MI aged 50–92 years and 240 healthy people aged 30–49 years without a history of MI (no-MI < 50). Results: There were statistically significant differences between the MI < 50 and MI ≥ 50 and no-MI < 50 groups regarding the family history of premature MI/ischaemic stroke and the percentage of patients with ≥2 relatives affected (10.8, 2.9, and 3.7%, respectively; p < 0.0001). There was a statistically significant difference in the patient age at the first MI occurrence among patients without a family history of premature CVD, those with 1 affected relative, and those with ≥2 affected first-degree relatives (56.6, 48.6 and 41.8 years, respectively) as well as those with affected first- and second-degree relatives (56.5, 50.7 and 47.0 years, respectively). Conclusions: A younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature MI/ischaemic stroke. Thus, the family history of premature atherosclerosis involving not only first- but also second-degree relatives seems to be a valuable factor in CVD risk evaluation in young people. Keywords: Myocardial infarction at a young age, Premature coronary artery disease, CVD family history
Background Coronary artery disease (CAD), according to a report of the American Heart Association, remains the leading cause of cardiovascular disease (CVD) deaths [1]. Regarding this, premature CAD seems to be one of the most pressing global issues in this area. * Correspondence: [email protected] The study has been presented at the recent EuroPrevent Congress (2019). Department of Cardiology, Centre of Postgraduate Medical Education, Grochowski Hospital, Grenadierów 51/59, 04-730 Warsaw, Poland
Data regarding the prevalence of myocardial infarction (MI) in young people differ according to assumptive cutoff age and study population. The percentage of patients aged < 35 years who underwent cardiac catheterization due to MI was determined to be 2% [2]. Recently published data reported that 10% of patients with MI, STelevation MI (STEMI), non-ST-elevation MI (NSTEMI), and unstable angina (UA) were ≤ 40 years of age [3]. Patients aged < 40 years represented 1.2% of all patients with MI in a Polish study [4]. When a cut-off age o
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