Zero-profile implant versus conventional cage-plate implant in anterior cervical discectomy and fusion for the treatment
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REVIEW
Open Access
Zero-profile implant versus conventional cage-plate implant in anterior cervical discectomy and fusion for the treatment of degenerative cervical spondylosis: a meta-analysis Haiyu Shao1, Jinping Chen1*, Bin Ru1, Feifei Yan2, Jun Zhang1, Shaonan Xu1 and Yazeng Huang1
Abstract Background: Zero-profile implant has become more and more popular in anterior cervical discectomy and fusion (ACDF) for the treatment of degenerative cervical spondylosis. However, there was no enough evidence judging its efficiency and safety. The aim of this analysis was to evaluate the efficacy and safety of Zero-profile implant compared with conventional cage-plate (CCP) in ACDF. Methods: All studies directly comparing the outcomes between the Zero-profile implant and CCP implant in ACDF were included, and the search strategy followed the requirements of the Cochrane Library Handbook. Two of the authors extracted relevant data and checked the accuracy independently using standardized data collection form. Results: Seven studies involving 560 patients were included, 262 in the Zero-profile group and 298 in the CCP group. Zero-profile implant had a lower rate of postoperative dysphagia at 2 weeks, 6 months, and 1 year (p = 0.0002, p = 0.008, and p = 0.001, respectively) than CCP implant. Zero-profile also reduced blood loss (p = 0.0001), while operation time and incidence of postoperative transient dysphagia had no statistical significance (p = 0.92, p = 0.42, respectively) between two groups. Conclusion: Based on the results of our analysis, the application of Zero-profile implant in ACDF had a lower rate of postoperative dysphagia at 2 weeks, 6 months, and 1 year than CCP implant. Zero-profile implant also had fewer blood loss during operation. More rigorous and adequately powered prospective randomized controlled trials with larger sample size are required to elucidate a more objective outcome. Keywords: Zero-profile, Anterior cervical discectomy and fusion, ACDF, Dysphagia, Degenerative cervical spondylosis
Introduction Since anterior cervical discectomy and fusion (ACDF) was first described by Smith and Robinson [1], the procedure has become the gold-standard operation for single- or multiple-level degenerative cervical spondylosis. The application of stand-alone cage with a titanium plate (conventional cage-plate (CCP)) in ACDF has become more and more popular since studies [2–5] showed that CCP had many advantages compared with the stand* Correspondence: [email protected] Haiyu Shao, M.D. was the first author. 1 Department of Orthopaedics, Zhejiang Provincial People’s Hospital, No.158, Shangtang Road, Hangzhou 310000, Zhejiang, China Full list of author information is available at the end of the article
alone cage: improving sagittal alignment, interbody fusion rate, and stability and preventing interbody graft dislocation. However, complications related to the plates were not rare, such as postoperative dysphagia, adjacent level degeneration, and soft tissue injury [6–8]. And, sometimes, it seems to be inesc
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