10.1 Sympathetic Responses to Ventricular Extrasystolic Beats in Obese Subjects without and with Sleep Apnoea
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High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Nervous System 10.1 Sympathetic Responses to Ventricular Extrasystolic Beats in Obese Subjects without and with Sleep Apnoea R. Dell’Oro (1), G. Seravalle (2), F. Quarti-Trevano (1), A. Rozzoni (1), M. Volpe (1), L. Magni (1), G. Grassi (1), G. Mancia (1) ` di Milano-Bicocca, Ospedale San Gerardo, Monza, Italy, (2)Istituto (1)Universita Auxologico Italiano, Milano, Italy Introduction. Ventricular extrasystolic beats (PVCs) trigger, along with an early and a late blood pressure (BP) fall and overshoot, an early sympatho-excitation and a late period of sympathoinhibition. The present study was designed to quantify the sympathetic response to PVCs in obesity, uncomplicated or complicated by sleep apnoea, i.e. conditions in which the adrenergic overdrive may be responsible for the increased of arrhythmogenic threshold. Methods. In 22 obese normotensive subjects (age 50.1±2.1 years, mean±SEM), 14 of which with and 8 without sleep apnoea, and in 14 age-matched healthy controls (C), both in Lown class less than II, we evaluated BP (Finapres), heart rate (HR, EKG) and muscle sympathetic nerve traffic (MSNA, microneurography) responses to isolated monofocal PVCs. Results. MSNA, quantified as bursts incidence corrected for HR, was significantly increased in obese without and with sleep apnoea (61.7± 2.2 and 74.8±2.5 bs/100hb respectively, p
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