10.4 Acute Administration of Vitamin C Decreases Sympathetic Nervous Activity and Blood Pressure in Hypertensive Patient
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High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Nervous System 10.4 Acute Administration of Vitamin C Decreases Sympathetic Nervous Activity and Blood Pressure in Hypertensive Patients R.M. Bruno (1), E. Daghini (1), L. Ghiadoni (1), I. Sudano (2), D. Versari (1), E. Duranti (1), A. Favilla (1), A. Magagna (1), S. Taddei (1), A. Salvetti (1) ` di Pisa, Pisa, Italy, (2)University Hospital, Zurich, Switzerland (1)Universita Introduction. Essential hypertension is characterized by both increased oxidative stress and sympathetic nervous system (SNS) hyperactivity. Experimental studies suggest that increased oxidative stress contributes to the development of hypertension through activation of the SNS. Aim. To determine whether an acute administration of the antioxidant vitamin C can influence SNS activity in hypertensive patients. Methods. Fifteen never treated, essential hypertensive patients were included. Heart rate (HR), noninvasive beat-to-beat blood pressure (BP, Portapres) and muscle sympathetic nervous activity (mSNA, microneurography) were monitored in basal conditions and until 20 minutes after infusion of vitamin C (3 g iv in 5 minutes). Venous samples for assessment of norepinephrine (NE), oxidative stress (maloniydialdehyde, MDA) and antioxidant capacity (ferric reducing ability of plasma, FRAP) were obtained before and at the end of recording. HR, BP and mSNA values were analyzed as means of 5 minutes at baseline and between 16’-20’ after infusion and expressed as mean ± SEM. Results. Vitamin C infusion significantly reduced oxidative stress (MDA from 5.4±0.8 to 4.6±0.6 micromol/L, p
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