10.3 Inhibition of NO-Synthase Modulates Sympathetic Nervous Activity in hypertensive Patients
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High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Nervous System 10.3 Inhibition of NO-Synthase Modulates Sympathetic Nervous Activity in hypertensive Patients R.M. Bruno (1), I. Sudano (2), L. Ghiadoni (1 ), A. Magagna (1), S. Taddei (1), A. Salvetti (1) ` di Pisa, Pisa, Italy, (2)University Hospital, Zurich, Switzerland (1)Universita Introduction. Experimental studies demonstrate that nitric oxide (NO) plays a fundamental role in the regulation of sympathetic nervous system (SNS) outflow, and subsequently in cardiovascular homeostasis. In healthy subjects the infusion of an inhibitor of NO-synthase (LNMMA) exerts sympathoexcitatory effects, suggesting that NO may inhibit SNS activity in humans. Aim. To investigate the relationship between NO and SNS activity in essential hypertensive patients. Methods. In 8 never treated, essential hypertensive patients, ECG, non invasive beat-to-beat blood pressure (BP, Portapres) and muscle sympathetic nervous activity (mSNA, microneurography) were recorded continuously in basal conditions and during infusion of LNMMA (bolus 3 mg/Kg iv followed by infusion at 3 mg/kg/h iv for 40’). Seven matched hypertensive patients were infused with metaraminol (MET), an alpha-adrenergic agonist (2 microg/Kg/min iv for 40’), to obtain the same increase in BP. Mean BP, heart rate (HR) and mSNA values were analyzed as means of 5 minutes and expressed in mean ± SEM. Results. Both LNMMA and MET increased mean BP in a similar fashion (LNMMA: from 104.6 ± 4.6 to 117.6 ± 6.1 mmHg, p
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