1057 Pulmonary artery size and function after Fontan operation at young age: assessment with phase contrast magnetic res
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BioMed Central
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Meeting abstract
1057 Pulmonary artery size and function after Fontan operation at young age: assessment with phase contrast magnetic resonance imaging Danielle Robbers-Visser*1, Frank Helderman2, Jan L Strengers3, Lennie van Osch-Gevers1, Livia Kapusta4, Peter MT Pattynama5, Ad JJC Bogers5, Rob Krams2 and Willem A Helbing1 Address: 1Erasmus MC – Sophia, Rotterdam, The Netherlands, 2Free University Medical Center, Amsterdam, The Netherlands, 3University Medical Center Utrecht, Utrecht, The Netherlands, 4UMC St Radboud, Nijmegen, The Netherlands and 5Erasmus MC, Rotterdam, The Netherlands * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A182
doi:10.1186/1532-429X-10-S1-A182
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A182 © 2008 Robbers-Visser et al; licensee BioMed Central Ltd.
Introduction
Results
little is known about the effects of long-term non-pulsatile flow on pulmonary artery (PA) growth after Fontan operation. Furthermore, the effects on flow variables and shear stress have not been studied in a patient group operated on at young age.
CMR scanning and dobutamine administration was well tolerated by all subjects without side effects. Results of the flow studies and shear stress determination are summarized in Table 1 (NS = not significant).
Conclusion In this study, we assessed PA size, flow variables, and shear stress long-term after Fontan operation at young age and compared them with healthy controls, using cardiovascular magnetic resonance (CMR) imaging.
PA diameter is normal in patients long-term after Fontan operation at young age. However, flow variables, distensibility and shear stress are significantly lower compared to healthy controls, implicating pulmonary endothelial and/ or vascular dysfunction.
Methods
References
14 patients (9 males, aged 13.1 ± 4.0 years, follow-up after Fontan completion 9.7 (5.4–16.8) years) and 17 healthy controls (9 males, aged 13.3 ± 2.3 years) were included. Flow measurements in the branch PA were made during a CMR study, using phase contrast velocity-encoded imaging. In patients, flow measurements were repeated during low-dose dobutamine stress of 7.5 μg/kg/min. Shear stress was determined according to a previously published method [1].
1.
Purpose
J Am Coll Cardiol 2005, 45:846-854.
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Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A182
http://jcmr-online.com/content/10/S1/A182
Table 1:
controls
patients, rest
patients, stress
p-value (controls vs patients)
p-value (rest vs stress)
Heart rate (/min) Stroke index (ml/m2) Total flow (ml/min/m2) Average f
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