1079 Detecting reperfused acute myocardial infarcts with cardiac phase-resolved balanced SSFP imaging
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Meeting abstract
1079 Detecting reperfused acute myocardial infarcts with cardiac phase-resolved balanced SSFP imaging Rohan Dharmakumar*, Nirat Beohar, Jain Mangalathu Arumana, Rodney Greene and Debiao Li Address: Northwestern University, Chicago, IL, USA * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A204
doi:10.1186/1532-429X-10-S1-A204
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A204 © 2008 Dharmakumar et al; licensee BioMed Central Ltd.
Introduction Combined CMR assessment of late-enhancement (LE) and edema provides a means for discriminating between acute and chronic myocardial infarctions (MI). Current myocardial edema imaging methods are limited to a single cardiac phase. Cine imaging that has the capacity to visualize myocardial edema (acute MI), may improve the efficiency of CMR exams.
Hypothesis Balanced SSFP (b-SSFP) imaging can be used for cardiac phase-resolved acute MI imaging since, (1) its intrinsic T2/ T1 signal weighting may be used to discriminate between edematous and healthy myocardial regions, and (2) it is routinely used for CMR assessment of function.
Methods Animal Preparation & Data Acquisition Yucatan mini-pigs (n = 11) were operated on using procedures and protocols approved by our institution. A balloon catheter was used to occlude the left circumflex artery for 90 minutes to induce MI. All MRI studies were performed using a Siemens Sonata scanner on day 3–4, post MI, and were breath-held and ECG-gated. Following scout scans and whole-heart shim, multiple short-axis 2D-bSSFP images were acquired in the cine mode covering the whole left ventricle. Scan parameters: voxel size = 0.9 × 0.9 × 6 mm3; flip angle = 45°; TR/TE = 3.1/1.5 ms; averages = 2–3; 20 cardiac phases. Short axis LE images covering the whole left-ventricle were acquired at mid systole follow-
ing intravenous infusion of a gadolinium chelate (Magnevist). Scan parameters: voxel size = 1.3 × 1.3 × 6 mm3; TR/ TE = 362/4; and TI = 200–240 ms. Data Analysis Based on trigger times, the corresponding LE and cine SSFP images were matched. On the basis of LE images, healthy regions of the myocardium were identified, and the mean and standard deviation (SD) of the signal intensities of these regions were computed. The infarct zone was identified as the myocardial region with greater than twice the SD of the mean signal intensity from the healthy regions. Using this criterion, the infarct zones were identified on a pixel-by-pixel basis and the total infarct areas and the corresponding average signal intensities of the infarct areas were computed. This was performed on every imaging slice positive f
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