Why do we see myocardial edema in acute myocardial infarcts with balanced SSFP imaging?
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BioMed Central
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Moderated poster presentation
Why do we see myocardial edema in acute myocardial infarcts with balanced SSFP imaging? Xiangzhi Zhou*1, Veronica Rundell1, Ying Liu1, Richard Tang1, Rachel Klein1, Shivraman Giri2, Saurabh Shah3, Sven Zuehlsdorff3, Orlando Simonetti2, Debiao Li1 and Rohan Dharmakumar1 Address: 1Northwestern University, Chicago, IL, USA, 2Ohio State University, Columbus, OH, USA and 3Siemens Medical Solutions USA, Inc., Chicago, IL, USA * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):M12
doi:10.1186/1532-429X-12-S1-M12
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/M12 © 2010 Zhou et al; licensee BioMed Central Ltd.
Introduction Recent studies have demonstrated that conventional balanced steady-state free precession (b-SSFP) cine imaging can identify regions of myocardial edema in-and-around acute myocardial infarctions (AMI). However, the underlying mechanisms of b-SSFP edema contrast are not well understood. A more detailed understanding of the contrast mechanisms at play may enable opportunities for optimization of SSFP-based edema contrast.
Purpose To investigate the mechanisms contributing to the b-SSFPbased edema contrast surrounding AMI in conventional cine b-SSFP images
Methods Dogs (n = 3) subjected to ischemia-reperfusion injury (LAD occlusion for 3 hours followed by reperfusion) were studied at baseline (pre-injury), 2-hours post-reperfusion (day 0), and on days 2, 5, and 7. Multiple breath-held short-axis cine b-SSFP images, and T2- and T1-maps were acquired at late diastole using a Siemens Espree (1.5 T) system. All studies were terminated with PSIR late-gadolinium-enhancement (LGE) acquisitions to confirm LAD infarction. Cine SSFP imaging was performed with TR/TE = 3.5/1.75 ms; flip angle = 70°; 20-25 phases. The cardiac phase corresponding to the T1 and T2 maps were identi-
fied from the cine b-SSFP images. On these SSFP images, and the relaxation maps, a semi-automated approach was used to identify the edematous territory. Using the Freeman-Hill equation for b-SSFP and the measured signal, T1 and T2 values for edematous and healthy territories, the relative contributions from relaxation and thermal magnetization (M0) effects were estimated.
Results Semi-automated and visual analysis did not identify regions of hyperenhancement in T1 and T2 maps, or SSFP or LGE images acquired under baseline conditions in any of the animals. Hyperintense LAD territories were readily identified on T1, T2, and cine SSFP images on days 0, 2, 5, and 7 in all dogs and the presence of AMI within the same territories was confirmed by LGE images (Figure 1). Mean relative contribut
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