1.11 Prevalence of Metabolic Alterations In Hypertensive Patients with Stable vs Unstable Angina
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High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Atherosclerosis and Inflammation 1.11 Prevalence of Metabolic Alterations In Hypertensive Patients with Stable vs Unstable Angina F. Paneni (1), S. Sciarretta (1), A. Ricotta (1), F. Marrara (1), F. Palano (1), G. Tocci (1), M. Testa (1), M. Volpe (1) (1)Division of Cardiology, II Faculty of Medicine, University of Rome “La Sapienza”, Sant’Andrea Hospital, Rome, Italy Introduction: Stable and unstable angina represent extremely different conditions, both by clinical and pathophysiological point of view. Aim. To investigate the prevalence of lipidic and metabolic alterations in a population of hypertensive patients with stable vs unstable angina. Methods. We prospectively enrolled 63 hypertensive patients with ischemic heart disease, aged from 30 to 70 years. The study population was divided in 18 patients with stable angina (SA) and 45 with unstable angina (UA). Patients with co-morbidities (i.e. diabetes, COPD etc.), previous myocardial infarction and left ventricular dysfunction (EF < 50%) were excluded. Therapy with statins or allopurinol represented exclusion criteria. In all patients we assessed blood glucose, total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), triglycerides (TG), apolipoprotein A1 (apoA1), apolipoprotein B (apoB), lipoprotein(a) [Lp(a)], uric acid, hs-PCR and serum creatinine. All patients underwent standard blood pressure measurement and transthoracic echocardiography (TTE). Left ventricular mass (LVM) was indexed to height^2,7 (LVM/h^2,7) and left ventricular hypertrophy (LVH) was defined as > 51 g/m^2,7 in men and > 47 g/m^2,7 in women. Inappropriate left ventricular mass (ILVM) was also calculated. All patients underwent coronary angiography. Results. Patients with UA presented higher levels of apoB, apoB/apoA1 ratio, Lp(a), uric acid, hsPCR and fasting glucose (p
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