11.12 Retinol Binding Protein (RBP-4) and Sympathetic Interaction in Overweight Hypertensives: Effect of Intensive Diete
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High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Therapy, Pharmacoeconomics and Pharmacovigilance 11.12 Retinol Binding Protein (RBP-4) and Sympathetic Interaction in Overweight Hypertensives: Effect of Intensive Dietetic Treatment A. Cabassi (1), G. Regolisti (1), E. Parenti (1), S. Tedeschi (1), E. Cremaschi (1), P. Greco (1), C. Maccari (1), S. Cavazzini (1), A. Bocchi (1), A. Borghetti (1), E. Fiaccadori (1) ` degli Studi di Parma, Parma, Italy (1)Universita Introduction. Body weight reduction represents the main step in the management of overweightobese hypertensive patients. Plasma RBP-4 levels are elevated in several experimental models of insulin resistance even if their relationship is less clear. Aim. Our study evaluated the effect of an intensive dietetic treatment on blood pressure levels, on homeostasis model assessment of insulin resistance index (HOMA-IR), on body weight change in a group of patients affected by high blood pressure (stage 1), overweight or obese (n=31, age 19-66 years, BMI 28,3-34,4 Kg/m2). Methods. Plasma RBP-4 and catecholamine levels were determined before and after the dietetic treatment period. Diet was administered for 24 weeks (caloric intake 1700 Kcal/die, Na
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