Interaction effect between long sleep duration in early pregnancy and prepregnancy overweight/obesity on gestational dia
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ORIGINAL ARTICLE
Interaction effect between long sleep duration in early pregnancy and prepregnancy overweight/obesity on gestational diabetes mellitus Weiye Wang 1,2 & Jiuming Zou 3
&
Qiang Fu 2 & Tao Huang 2 & Mengjun Li 2 & Zhao Yao 2 & Linbing Zou 4
Received: 29 January 2020 / Accepted: 2 September 2020 # Research Society for Study of Diabetes in India 2020
Abstract Objective To explore the individual and interaction effects of sleep duration and prepregnancy body mass index (BMI) on gestational diabetes mellitus (GDM). Methods Pregnant women who attended antenatal visits in 2 hospitals were selected as the study population. Sleep duration and prepregnancy BMI were collected through a semiquantitative questionnaire, and GDM was diagnosed according to an oral glucose tolerance test (OGTT). Results In total, 196 women with GDM and 304 controls were included. Compared with the normal weight women, the prepregnancy overweight/obese group had an increased risk of GDM (OR: 7.04, p < 0.001); compared with women who slept 7–8.9 h/night, women who slept < 7, 9–9.9, or ≥ 10 h/night had an increased risk of GDM (all p < 0.001). The participants with a combination of long sleep duration (≥ 10 h/night) and prepregnancy overweight/obesity had the highest risk of GDM (OR = 39.57, p < 0.001), and this effect was greater than the product of the individual effects of a long sleep duration and overweight/ obesity (p value of the interaction 0.007). Conclusions A short or long sleep duration in early pregnancy and prepregnancy overweight/obesity is related to GDM, and there is a synergic effect between a long sleep duration and overweight/obesity on GDM. Keywords Gestational diabetes mellitus . Body mass index . Obesity . Sleep duration . Interaction
Introduction
* Jiuming Zou [email protected] 1
Department of Epidemiology and Health Statistics, School of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao, Shandong 266021, People’s Republic of China
2
Department of Public Health and Preventive Medicine, School of Medicine, Jinggangshan University, 28 Xueyuan Road, Ji’an, Jiangxi 343009, People’s Republic of China
3
Department of Clinical Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, 136 Jingzhou Road, Xiangyang, Hubei 441021, People’s Republic of China
4
Department of Obstetrics, Anhui Women and Children’s Health Care Hospital, 15 Yimin Road, Hefei, Anhui 230001, People’s Republic of China
Gestational diabetes mellitus (GDM) is among the most common diseases occurring during pregnancy [1]. GDM continues to be a major cause of morbidity and is currently a major public health issue worldwide [2]. According to the statistics of the International Diabetes Association (IDF), approximately one-seventh of newborns worldwide in 2015 were affected by GDM [3]. As the proportions of overweight and obese people and older pregnant women increase, and due to the continuous changes in the diagnostic criteria for GDM, the global incidence of GDM has increased ye
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