12.4 Effects of Triglyceridaemia on Carotid Wall Thickness in Treated Essential Hypertension
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High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Vessels and Endothelium 12.4 Effects of Triglyceridaemia on Carotid Wall Thickness in Treated Essential Hypertension C. Giannattasio (1), M. Failla (1), P. Campadello (1), D. Dozio (1), P. Canova (1), A. Cafro (1), E. Montemerlo (1), M. Rigoldi (1), E. Scanziani (1), I. Viscardi (1), F. Madotto (1), A. Capra (1), G. Mancia (1) ` di Milano-Bicocca and Ospedale San Gerardo di (1)Clinica Medica Universita Monza, Monza, Italy Introduction. Age, blood pressure (BP) and serum total cholesterol have been shown to correlate with the number and size of atherosclerotic lesions. Less is known however, on whether serum triglycerides also participate in the determination of atherosclerosis, particularly in subjects in whom BP is reasonably well controlled by treatment and total cholesterol is not increased. Methods. We studied 292 consecutive hypertensive non diabetic patients (187 males, age 19-86 years) on treatment with several anti-hypertensive drugs in various combinations and dosages. Intima-media thickness (IMT) was measured at the common carotid artery level by an echocolor-Doppler device (Phillips Sonos 7500). Other measurements consisted of blood pressure (sphygmomanometry), heart rate (HR, palpatory method) body mass index (BMI), serum total cholesterol, LDL-cholesterol, triglycerides. Results. In the group as a whole, mean age (±SE) was 54.3±0.8 years, BMI 26±0.2 g/m2, BP (systolic/ diastolic) 142±1/86±0.6 mmHg, HR 65±0.5 b/min, and serum total cholesterol, LDL cholesterol and triglycerides, 197±2, 116±2 and129±5 mg/dl, respectively. Mean carotid IMT was 0.68± 0.01 mm and its individual values showed a significant correlation with age (r=0.54, p
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