138 Relationship between coronary calcification and endothelium dependent coronary vaso-reactivity in asymptomatic diabe
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BioMed Central
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Meeting abstract
138 Relationship between coronary calcification and endothelium dependent coronary vaso-reactivity in asymptomatic diabetic patients without overt coronary artery disease Olakunle Akinboboye1, Yi Wang2, Michael Jerosch-Herold2, Karen Ngai1, M Rizwan Khalid*1, Rafael Dim3, Kathy McGrath2 and Marguerite Roth2 Address: 1New York Hospital Medical Center Queens, Flushing, NY, USA, 2Saint Francis Hospital, Roslyn, NY, USA and 3SUNY Downstate, Brooklyn, NY, USA * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A39
doi:10.1186/1532-429X-10-S1-A39
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A39 © 2008 Akinboboye et al; licensee BioMed Central Ltd.
Introduction The relationship between coronary calcification and endothelium dependent coronary vaso-reactivity in patients with diabetes mellitus is poorly understood.
Purpose We hypothesize that endothelium dependent coronary vaso-reactivity; in asymptomatic diabetic patients without myocardial ischemia is impaired in vascular territories with coronary calcification.
Methods We studied 23 (mean age 63 ± 10, 19 M, 4 F) patients with type II DM, without history, symptom or ECG evidence of CAD. The subjects underwent 1-day rest-stress adenosine nuclear stress test, assessment of coronary calcification by EBCT and absolute measurement of myocardial blood flow at rest (MBF-R), and following cold-water hand immersion for 1 minute (MBF-C). All imaging studies were performed within 24 hours. Flow measurements by CMRI was performed using saturation recovery TurboFLASH imaging sequence: TR/TE/TI/FA = 2.9 ms/1.3 ms/ 90 ms/6°, data matrix 128 × 70, and usual voxel spatial resolution 3.5 × 1.9 × 8 mm3. Contrast dose was 0.05 mmol/kg (Omniscan, Amersham). All scans were processed in a blinded fashion. Using Medis software (Leiden University, the Netherlands), basal, mid-cavity and apical slices were divided into 6 equal transmural sectors. After
correction for coil sensitivity variations, model independent deconvolution of myocardial signal intensity curves in the sectors, with blood pool signal intensity curves was performed. MBF-R and MBF-C in mls/g/min were determined. Endothelium dependent perfusion reserve (MPR) in these sectors were calculated as the ratios of MBF-C to MBF-R in each sector. The sectors wre subsequently grouped based on standard coronary vascular distribution. Difference between means of two groups of patients was calculated using Student's t-test while One-way ANOVA model was utilized to compare means amongst three groups. P-value of < 0.05 was considered significant The vascular sectors were stratified into 3 groups (A,
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