2077 Detection and differentiation of myocardial delayed contrast enhancement patterns by cardiac mri in patients with e
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Meeting abstract
2077 Detection and differentiation of myocardial delayed contrast enhancement patterns by cardiac mri in patients with end stage renal disease Constanze Merten*, Christoph Merbach, Vedat Schwenger, Martin Zeier, Hugo A Katus, Evangelos Giannitsis and Henning Steen Address: University Hospital Heidelberg, Heidelberg, Germany * Corresponding author
from 11th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 1–3 February 2008 Published: 22 October 2008 Journal of Cardiovascular Magnetic Resonance 2008, 10(Suppl 1):A346
doi:10.1186/1532-429X-10-S1-A346
Abstracts of the 11th Annual SCMR Scientific Sessions - 2008
Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1532-429X-10-S1-info.pdfThis abstract is available from: http://jcmr-online.com/content/10/S1/A346 © 2008 Merten et al; licensee BioMed Central Ltd.
Introduction Cardiovascular disease is a common complication in patients with end stage renal disease (ESRD) being the leading cause for mortality in this group of patients. From literature we know about the high prevalence of coronary artery disease among patients with ESRD with up to 50% of patients suffering fatal myocardial infarction. Furthermore it is known from autopsy studies that the majority of patients with ESRD develop interstitial myocardial fibrosis. Myocardial fibrosis can be accurately and non-invasively be detected by contrast-enhanced cardiac MRI.
Purpose We sought to assess the presence of distribution patterns of delayed contrast enhancement (DCE) in patients with ESRD listed for kidney transplantation (NTX).
was classified as ischemic-type DCE. Intramural, spotted, subepicardial or diffuse DCE was classified as nonischemic-type DCE.
Results In 4 of the 62 patients DCE image quality was insufficient, so 58 patients could be included into the final analysis. Patient characteristics are listed in table 1. Any type of DCE of detected in a 57 of 58 patients (98%). Differentiation of the enhancement pattern revealed evidence of prior myocardial infarction in 21 patients (36%). Non-ischemic-type DCE was found in a total 51 of 58 patients (88%), with most affected segments showing a spotted DCE. In 15 of the 21 patients with evidence of myocardial infarction DCE of the non-ischemic-type was seen in additional segments.
Conclusion Methods 62 patients with ESRD listed for NTX underwent cardiac MRI using a clinical 1.5 T scanner. DCE (gadolinium at 0.2 mmol/kg bw) images were acquired in continuous short-axis slices covering the left ventricle (sequence). MR images were analysed by consensus-reading of two experienced observers using the 17-segment-model regarding the presence and distribution of DCE. According to its pattern DCE was classified either as ischemic-type or nonischemic-type DCE. Subendocardial and transmural DCE
Myocardial infarction detected by the presence of ischemic-type DCE is a common finding among patients with ESRD listed for NTX
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