2D acoustofluidic patterns in an ultrasonic chamber modulated by phononic crystal structures
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RESEARCH PAPER
2D acoustofluidic patterns in an ultrasonic chamber modulated by phononic crystal structures Qiang Tang1 · Pengzhan Liu2 · Xin Guo1 · Song Zhou1 · Yuwei Dong1 Received: 20 July 2020 / Accepted: 5 October 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Controllable manipulation of micro/nano-particles and biological organisms are essential for the engineering development of miniaturized lab-on-a-chip systems in the application of physical, chemical, and biological researches. In this paper, a series of phononic crystal structure based acoustofluidic devices, which are actuated by incident plane wave at different frequencies, have been proposed and numerically investigated for micro-particle manipulation. The interaction between different phononic crystal structures and ultrasonic waves, providing reflection, scattering and diffraction, can generate diverse spatial variations of sound field distribution along the wave propagation path. The combination of phononic crystal structures and lab-on-a-chip devices is beneficial to overcome the monotonousness of the acoustofluidic field distribution for various physical and biochemical applications. The movement trajectories of micro-particles under the influence of acoustic radiation forces and acoustic streaming induced drag forces are also simulated to demonstrate the particle manipulation capability of the designed acoustofluidic device. Our simulation results suggest the possibility of considering phononic crystal structures as an effective ingredient to customize acoustofluidic field for constituting diverse lab-on-a-chip devices in the investigation of rapid microfluidic mixing and non-invasive manipulation of bio-organisms. Keywords Acoustofluidic field · Phononic crystal structure · Sound wave modulation · Micro-particle manipulation
1 Introduction Integrated microfluidic devices, also known as “lab-ona-chip” systems (Folch 2012), have achieved increasing attention and played a fundamental role in the field of micro-/nano-scale particle manipulation (Li et al. 2013), biochemical reaction (Ohno et al. 2010), total analysis of bio-samples (Lisowski and Zarzycki 2013), locomotion mechanism of autonomous micro/nanomachines (Lu et al. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10404-020-02394-8) contains supplementary material, which is available to authorized users. * Qiang Tang [email protected] 1
Jiangsu Provincal Engineering Research Center for Biomedical Materials and Advanced Medical Devices, Faculty of Mechanical and Material Engineering, Huaiyin Institute of Technology, Huaian 223003, China
State Key Lab of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China
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2019), point-of-care diagnostics (Frank 2013), and at-home tests for various health issues (Srinivasan et al. 2004), and so on. However, there have been limitations and challenges in the development process, in particular wit
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