5-HT2C Receptors in the Pathophysiology of CNS Disease
Research of 5-HT2c receptors stretches back twenty-five years, and while much of it has been productive, the past decade of research has been extraordinary in terms of both amount produced and insights gained. It is hardly surprising that 5-HT2c receptor
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Giuseppe Di Giovanni • Ennio Esposito Vincenzo Di Matteo Editors
5-HT2C Receptors in the Pathophysiology of CNS Disease
Editors Giuseppe Di Giovanni University of Malta Department of Physiology and Biochemistry Msida, Malta [email protected]
Vincenzo Di Matteo Consorzio Mario Negri Sud Centro di Ricerche Farmacologiche e Biomediche Chieti, Italy [email protected]
Ennio Esposito Consorzio Mario Negri Sud Centro di Ricerche Farmacologiche e Biomediche Chieti, Italy [email protected]
ISBN 978-1-60761-940-6 e-ISBN 978-1-60761-941-3 DOI 10.1007/978-1-60761-941-3 Springer New York Dordrecht Heidelberg London © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
To my wife Samantha, For her abundant support, for her patience and understanding, and for her love G. Di Giovanni
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Preface
Accepting the challenge of editing the first book on a subject is a risky business, particularly if you attempt to produce an overview in the research of 5-HT2C receptors, an area now going back over 25 years with so productive results. Nevertheless, I have embarked on this unique editorial enterprise with the aim of giving pleasure to the readers and researchers and not least to myself, confident that it will be instrumental in future research in 5-HT2C pathophysiology. A few years ago Bryan Roth edited, for the same series “The Receptors,” a very fine volume on serotonin receptors. The present volume is a further development of this and is a thorough examination of the 5-HT2C receptor subclass, needed to cover the extraordinary amount of research into nearly every aspect of 5-HT2C receptor function that has recently emerged. This is not surprising, considering that the 5-HT2C receptor is a prominent central serotonin receptor subtype, widely expressed within the central and the peripheral nervous system and is thought to play a major role in the regulation of a plethora of behaviors. Therefore, it has been shown by experimental and clinical observation that it may represent a possible therapeutic target for the development of drugs for a range of CNS disorders such as s
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