Advancement in the Pathophysiology of Cerebral Stroke
This book provides detailed and comprehensive mechanistic insights of the various risk factors that lead to the ischemic stroke and the novel therapeutic interventions against it. The first section discusses the different ischemic cerebral stroke-induced
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cement in the Pathophysiology of Cerebral Stroke
Advancement in the Pathophysiology of Cerebral Stroke
Ranjana Patnaik • Amit Kumar Tripathi Ashish Dwivedi Editors
Advancement in the Pathophysiology of Cerebral Stroke
Editors Ranjana Patnaik School of Biomedical Engineering Indian Institute of Technology (Banaras Hindu University) Varanasi, Uttar Pradesh, India
Amit Kumar Tripathi School of Biomedical Engineering Indian Institute of Technology (Banaras Hindu University) Varanasi, Uttar Pradesh, India
Ashish Dwivedi Department of Zoology Banaras Hindu University Varanasi, Uttar Pradesh, India
ISBN 978-981-13-1452-0 ISBN 978-981-13-1453-7 (eBook) https://doi.org/10.1007/978-981-13-1453-7 Library of Congress Control Number: 2019931918 © Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Contents
1 Cerebral Stroke: An Introduction���������������������������������������������������������� 1 Amit Kumar Tripathi 2 Inflammation, Oxidative Stress, and Cerebral Stroke: Basic Principles���������������������������������������������������������������������������������������� 11 Shashi Kant Tiwari, Priyanka Mishra, and Tripathi Rajavashisth 3 Stroke Induced Blood-Brain Barrier Disruption���������������������������������� 23 Amit Kumar Tripathi, Nirav Dhanesha, and Santosh Kumar 4 Ischemic Stroke-Induced Endoplasmic Reticulum Stress�������������������� 43 Namrata Rastogi and Vikas Kumar Srivastava 5 The Role of Autophagy in Ischaemic Stroke: Friend or Foe?�������������� 59 Komal Saraswat, Raushan Kumar, Syed Ibrahim Rizvi, and Abhishek Kumar Singh 6 Critical Role of Mitochondrial Autophagy in Cerebral St
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