5.1 Cardiac Natriuretic Peptides Reflect Left Atrial Volume (LAV) and Capture Longitudinal Changes in LAV in End-Stage R
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Heart 5.1 Cardiac Natriuretic Peptides Reflect Left Atrial Volume (LAV) and Capture Longitudinal Changes in LAV in End-Stage Renal Disease Patients G. Tripepi (1), F.A. Benedetto (1), F. Mallamaci (1), L.S. Malatino (2), C. Zoccali (1) (1)CNR-IBIM, Reggio Calabria; (2)Istituto di Medicina Interna "L. Condorelli", Catania, Italy Introduction. Left atrial volume (LAV) has recently emerged as a prognostic factor which can be used for risk stratification and risk monitoring in patients with end-stage renal disease (ESRD). Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are two biomarkers which reflect atrial and ventricular pressures and left ventricular mass but the relationship of these peptides with LAV are still scarcely characterised. Aim. To test the relationship between ANP and BNP with LAV and with LAV changes over a followup of 17±2 months. Methods. This longitudinal study was performed in a cohort of 151 ESRD patients (age: 57±12 years; M: 60% and F: 40%). LAV was significantly higher in haemodialysis patients than in healthy subjects (P
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