5.18 Cardiovascular and Metabolic Predictors of Progression to Overt Hypertension in a Population with Basal High-Normal
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Heart 5.18 Cardiovascular and Metabolic Predictors of Progression to Overt Hypertension in a Population with Basal High-Normal Blood Pressure Levels: The Strong Heart Study M. De Marco (1), M. Chinali (1), M.J. Roman (2), E.T. Lee (3), M. Russell (4), B.V. Howard (5), G. de Simone (1), R.B. Devereux (2) ` di Napoli “Federico II”, Napoli, Italy; (2)Weill Cornell Medical (1)Universita College, New York, USA; (3)University of Oklahoma, Oklahoma City, USA; (4)Medstar Research Phoenix, Phoenix, USA; (5)Medstar Research Institute, Hyattsville, USA Introduction High-normal blood pressure (BP) (accordingly to ESC-ESH guidelines) is a condition at high risk of progression to arterial hypertension (HTN), but is still not well established which metabolic and cardiac characteristics could predict future development of overt HTN. Methods. 369 participants from the Strong Heart Study, free of anti-hypertensive treatment and without prevalent cardiovascular disease or significant valve abnormalities, were analyzed (65% women; 48% diabetics; 59±7 years). All participants underwent echocardiographic, anthropometric and laboratory testing. Incidence of HTN was determined over a 4-years follow-up. The risk of development of HTN was evaluated taking in account the impact of anthropometric and metabolic profile and subsequently, of the echocardiographic in hierarchical regression models. Results. 4-years follow-up incidence of HTN was 52%. Diabetes (ADA criteria) was a strong predictor of HTN (OR= 2.53 [1.58-4.04]; p0.05). Accordingly, analysis was performed separately in participants with baseline diabetes. Among diabetic participants incidence of HTN was 64% (versus 41% in non diabetics; p
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