6.13 Correlation Between TSH and Blood Pressure and Thyroid Diseases Prevalence in a Cohort of Patients with Primary Ald
- PDF / 44,821 Bytes
- 1 Pages / 592.441 x 751.181 pts Page_size
- 89 Downloads / 148 Views
High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Hormonal Mechanisms 6.13 Correlation Between TSH and Blood Pressure and Thyroid Diseases Prevalence in a Cohort of Patients with Primary Aldosteronism F. Turchi (1), V. Ronconi (1), A. Taccaliti (1), M. Boscaro (1), G. Giacchetti (1) ` Politecnica delle Marche, Clinica di Endocrinologia, Ancona, Italy (1)Universita Introduction. Recent epidemiological studies suggest a correlation between serum thyrotropin (TSH) and blood pressure (BP) in subclinical thyroid dysfunction and into euthyroid range. Aim. to evaluate a correlation between TSH levels and blood pressure and to analyze the prevalence of thyroid diseases in a cohort of patients with primary aldosteronism (PA). Methods. We studied 60 patients with PA: 27 females and 33males, with mean age of 51 ± 11 years. In all patients we tested thyroid function, antibodies and ultrasonography, office and 24-h ambulatory blood pressure, serum and urinary electrolytes, upright plasma renin activity (PRA) and plasma aldosterone. Moreover a simultaneous 12-lead electrocardiogram (ECG) was recorded. Results. The regression analysis showed a positive and statistically significant correlation between TSH and office diastolic BP (r2=0.103, p=0.02). There was also an increase in office systolic BP and 24-h ambulatory BP with increasing TSH but these data were not statistically significant. Moreover different BP values were found analyzing TSH quartiles: the mean office diastolic BP in the first TSH quartile was 97 ± 13mmHg, in the highest was 103 ± 18 mmHg. The same increasing trend of TSH levels was confirmed for mean day-time diastolic BP (84 ± 13 mmHg in the lowest and 91 ± 11 mmHg in the highest quartile) and for mean night-time BP (79 ± 11 in the first and 84 ± 12 mmHg in the highest quartile). No significant correlations between TSH and PRA, plasma aldosterone, plasma aldosterone/PRA ratio, serum potassium were found. 30 percent of patients presented abnormalities at ECG; these alterations correlated positively with TSH, aldosterone and potassium levels. The prevalence of thyroid diseases in PA patients was 47%: 74% of these patients had thyroid antibodies, 68% of them had ultrasonographic alterations; 22% of PA patients were affected by hyperthyroidism and 10% of them were affected by hypothyroidism. Conclusions. For the first time this study shows a positive correlation between TSH and blood pressure in patients with PA, as reported in the literature in essential hypertension.
Data Loading...
