8.2 Glomerular Filtration Rate by Creatinine and Cystatin C Measurements in Essential Hypertensive Patients
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Kidney 8.2 Glomerular Filtration Rate by Creatinine and Cystatin C Measurements in Essential Hypertensive Patients S. Cottone (1), M. Guarneri (1), R. Riccobene (2), F. Tornese (1), G. Giammarresi (2), C. Canale (2), G. Cerasola (2), R. Arsena (1), on behalf of R. Arsena (1)Cattedra di Nefrologia, Dipartimento di Medicina Interna, Malattie ` di Palermo, Palermo; (2)Cattedra di Cardiovascolari e Nefrourologia, Universita Medicina Interna, Dipartimento di Medicina Interna, Malattie Cardiovascolari e ` di Palermo, Palermo, Italy Nefrourologia, Universita Introduction. In spite of the adoption of new equations to estimate glomerular filtration rate (GFR), it is very difficult to estimate GFR in patients with different stages of chronic kidney disease. Aim. To test the reliability of plasma cystatin C to reflect GFR estimation. Methods. The radionuclide clearance measurement for the assessment of GFR was considered as gold standard. The radioisotopic GFR was compared with the GFR estimation by creatinine clearance, Cockcroft & Gault, C&G/BSA formulas, and Mayo Clinic and MDRD equations and with five equations using plasma cys CGFR was assayed by radionuclide clearance in 110 essential hypertensive patients in basal conditions. Plasma creatinine (Jaff`e reaction) and plasma cystatin C (nephelometric method) were assayed. GFR estimating equations were: for creatinine its clearance, Cockcroft & Gault, C&G/BSA, Mayo Clinic and MDRD equation s; for cystatin C Perkins, Rule, Tan MacIsaac, Arnal-Dade equations. Patients with acute inflammation, tumour and thyroid disease were excluded. Results. In all hypertensive patients plasma cys C correlated with GFR estimated by radioisotopic method (r = -0.55, p
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