9.18 Hypertension and Systemic Inflammation are Associated with Hyperleptinaemia Independently of Adiposity and Insulin
- PDF / 45,249 Bytes
- 1 Pages / 592.441 x 751.181 pts Page_size
- 16 Downloads / 142 Views
High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Metabolic Aspects and Mechanisms 9.18 Hypertension and Systemic Inflammation are Associated with Hyperleptinaemia Independently of Adiposity and Insulin Resistance F. Galletti (1), L. De Lia (1), D. De Plama (1), R. Ippolito (1), O. Russo (1), R. Iacone (1), P. Strazzullo (1) ` di Napoli “Federico II”, Napoli, Italy (1)Universita Introduction. In a previous study, we described the predictive value of circulating leptin (LPT) levels on the development of the metabolic syndrome; here we evaluated the hypothesis that obese patients with different levels of plasma LPT present a different cardiovascular involvement. Methods. We included 972 male participants of the 1994-5 follow-up visit of the Olivetti Heart Study, for whom plasma level s of LPT and fasting serum insulin were available. The population sample was stratified according to the median of plasma LPT distribution (2.97 ng/ml), in subjects with low (lLPT) and high LPT (hLPT) levels. Furthermore, the two groups were accurately matched for age and BMI, with a precision to the first decimal digit. Results. We identified two subgroups of 207 individual s each comparable for age (lLPT = 51. 4 ± 0.5 vs hL PT = 51.8 ± 0.6 years, mean ± SE) and BMI (27.1 ± 0.2 vs 27.1 ± 0.2 kg/m2). However, the two groups were different in terms of blood pressure (BP), the hLPT group showing higher BP (lLPT:129 ± 1.3/83 vs. 0.7 ± hLPT: 133 ± 1.1/86 ± 0.6 mm Hg, p 25, n = 164 for each group, lLPT BMI 27. 9 ± 0.2; age 51.1 ± 0.5; hLPT: BMI 27.9 ± 0.2, age 52. 2 ± 0.6), the two subgroups differed significantly, upon adjustment for umbilical circumference, for both BP (129 ± 1.2 / 83 ± 0.6 vs 132 ± 1.2 / 85 ± 0.6, p
Data Loading...
