9.19 Relationship of Serum Insulin, Leptin and Adiponectin and their Changes Over Time to the Incidence of Hypertension
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High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Metabolic Aspects and Mechanisms 9.19 Relationship of Serum Insulin, Leptin and Adiponectin and their Changes Over Time to the Incidence of Hypertension in Men: Results of the Olivetti Prospective Heart Study S. Avallone (1), F. Galletti (1), R. Iacone (1), O. Russo (1), F.P. Cappuccio (2), A. Siani (3), A. Barbato (1), A. Venezia (1), M. Miller (2), R. Ippolito (1), P. Strazzullo (1) ` di Napoli “Federico II”, Dipartimento di Medicina Clinica e (1)Universita Sperimentale, Napoli, Italy, (2)University of Warwick Medical School, Coventry, UK, (3)Istituto di Scienza dell ’Alimentazione, CNR, Avellino, Italy Introduction. To investigate the relationship of serum insulin (I), leptin (L) and adiponectin (A) levels and their changes over time to the incidence of hypertension (HT) in men. Methods. The study population was made of 479 adult untreated normotensive (NT) men (mean age 51.6, range 25-74 years) participating in the 1994-1995 examination of the Olivetti Heart Study, who were examined again in 2002-2004 (8-year average follow-up) and had serum I, L and A measured in both occasions. Incident HT in 2002-20004 was defined as a BP more than 140 and/or 90 mmHg or current pharmacological treatment. Results. Both at baseline and at follow-up examination I and L were positively related and A inversely related to SBP and DBP (p between
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