Serum leptin and total dietary energy intake: the INTERLIPID Study
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ORIGINAL CONTRIBUTION
Serum leptin and total dietary energy intake: the INTERLIPID Study Yasuyuki Nakamura • Hirotsugu Ueshima • Nagako Okuda • Yoshitaka Murakami Katsuyuki Miura • Yoshikuni Kita • Tomonori Okamura • Akira Okayama • Tanvir C. Turin • Sohel R. Choudhry • Beatriz Rodriguez • J. David Curb • Jeremiah Stamler
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Received: 5 August 2012 / Accepted: 16 November 2012 Ó Springer-Verlag Berlin Heidelberg 2012
Abstract Purpose It has been hypothesized that leptin-induced appetite suppression is impaired in obese individuals, but little human evidence is available documenting this. We investigated relations between serum leptin and total energy intake using INTERLIPID/INTERMAP data on Japanese–Americans in Hawaii and Japanese in Japan. Methods Serum leptin and nutrient intakes were examined by standardized methods in men and women aged 40–59 years from two population samples, one Japanese– American in Hawaii (88 men, 94 women), the other Japanese in central Japan (123 men, 111 women). Multiple linear regression analyses stratified by BMI category (\25 kg/m2, 25–29.9 kg/m2, and C30 kg/m2) with adjustment for possible confounders were used to examine the relation between log-leptin and total dietary energy intake.
Results In multivariate regression analyses, in those with BMI \ 25 kg/m2 and in those with BMI between 25 and 29.9 kg/m2, log-leptin was not significantly related to total dietary energy intake; in those with BMI C 30 kg/m2, it was significantly inversely related to total dietary energy intake (P = 0.029), independent of body weight and physical activity. Physical activity score was significantly positively related to total dietary energy intake only in participants with BMI \ 25 kg/m2 (P \ 0.001). Conclusion Leptin was significantly inversely associated with dietary energy intake in obese persons, but not in overweight and normal-weight persons. Keywords Leptin Japanese in Japan and Hawaii Obesity Body mass Total energy intake Population study
J. David Curb is deceased on January 8, 2012. This study is conducted for the INTERLIPID Research Group. Y. Nakamura (&) Cardiovascular Epidemiology, Kyoto Women’s University, 35 Imakumano Kitahiyoshi-cho, Higashiyama-ku, Kyoto, Kyoto 605-8501, Japan e-mail: [email protected] Y. Nakamura H. Ueshima K. Miura Y. Kita T. C. Turin Department of Health Science, Shiga University of Medical Science, Otsu, Japan N. Okuda A. Okayama The First Institute of Health Service, Japan Anti-Tuberculosis Association, Tokyo, Japan Y. Murakami Department of Medical Statistics, Shiga University of Medical Science, Otsu, Japan
T. Okamura Department of Preventive Cardiology, National Cardiovascular Center, Suita, Japan S. R. Choudhry Department of Epidemiology and Research, National Heart Foundation Hospital and Research Institute, Dhaka, Bangladesh B. Rodriguez J. David Curb Department of Geriatric Medicine, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA J. Stamler Feinberg School of Medicine, Northwestern University, Chica
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