A case report of ultrasonographic findings in bilateral diffuse Uveal melanocytic proliferation
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CASE REPORT
Open Access
A case report of ultrasonographic findings in bilateral diffuse Uveal melanocytic proliferation Jingli Guo1,2,3†, Wenyi Tang1,2,3†, Wei Liu1,2,3*, Min Zhou1,2,3, Qing Chang1,2,3, Chunhui Jiang1,2,3, Gezhi Xu1,2,3, Wenji Wang1,2,3 and Qian Chen1,2,3*
Abstract Background: To report undescribed characteristics of patients with bilateral diffuse uveal melanocytic proliferation (BDUMP) on ultrasound biomicroscopy (UBM) and high-frequency B-scan ultrasonography. Case presentation: Two of four participants presented with worsening bilateral vision after previously diagnosed primary pulmonary or ovarian carcinoma. The other two patients were diagnosed with lung carcinoma after presentation with BDUMP. All patients had ciliary body nevi-like lesion in combination with iris or ciliary body cysts, and uveal thickening on UBM. Focally elevated choroidal nevi-like lesion and exudative retinal detachment with choroidal thickening were detected with B-scan ultrasonography. Conclusions: Our case series demonstrates the uveal characteristics of patients with BDUMP based on highfrequency B-scan ultrasonography and UBM. Ultrasonographic findings are crucial in the diagnosis of BDUMP because it is occult in nature. Keywords: Bilateral diffuse uveal melanocytic proliferation, Ultrasound biomicroscopy, High-frequency B-scan ultrasonography, Ciliary body nevi
Background Bilateral diffuse uveal melanocytic proliferation (BDUMP) is an infrequent paraneoplastic ocular syndrome with remarkable vision loss. The characteristic manifestations were described by Gass and colleagues [1], including the presence of multiple orange-red lesions with early hyperfluorescence on fundus fluorescein angiography (FFA), scattered melanocytic tumors in a diffusely thickened uveal tract, exudative retinal detachment, and rapidly progressive cataract. As well as these five cardinal signs, few studies have paid attention to the abnormalities of the iris and ciliary body lesions because * Correspondence: [email protected]; [email protected] † Jingli Guo and Wenyi Tang contributed equally to this work. 1 Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai 200031, China Full list of author information is available at the end of the article
of its occult manifestations. Here, we report a case series of patients with BDUMP, characterized by ciliary body and choroidal nevi-like lesions in combination with iris or ciliary body cysts, and diffuse uveal thickening detected with ultrasound biomicroscopy (UBM) and highfrequency B-scan ultrasonography in order to provide more theoretical basis for clinical diagnosis.
Case presentation Case 1
A woman in her 60s presented with blurred vision and photophobia in both eyes, which had persisted for 3 months. She had previously been diagnosed with clear cell adenocarcinoma of the ovary in 2003 and was treated with surgical resection, with a total hysterosalpingo-oophorectomy, and chemotherapy
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