A comprehensive quantitative comparison of myocardial motion in mice, rabbits and humans using phase contrast MRI
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POSTER PRESENTATION
Open Access
A comprehensive quantitative comparison of myocardial motion in mice, rabbits and humans using phase contrast MRI Bernd A Jung1*, Katja E Odening2, Erica Dall’Armellina3, Daniela Föll2, Jurgen E Schneider3 From 15th Annual SCMR Scientific Sessions Orlando, FL, USA. 2-5 February 2012 Background Genetically manipulated animals like mice or rabbits play an important role in the exploration of human cardiovascular diseases. It is therefore crucial to identify animal models that closely represent the human cardiac phenotype. Methods Phase contrast MRI [1] was used to measure regional three-directional LV myocardial motion with high temporal resolution in mice (N=18), rabbits (N=8), and humans (N=20). Radial, long-axis, and rotational myocardial velocities were acquired in left ventricular basal, mid-ventricular, and apical short-axis locations (see Table 1 for scan parameters). Positive radial velocities indicate contraction, positive long-axis velocities motion from base to apex, positive in-plane rotation is defined as clockwise viewed from apex to base. Global (averaged over the entire segmentation mask) and regional (by partitioning the LV into 16 segments according to the 17-segment model by the AHA) motion patterns were analyzed. Peak velocities were determined as well as velocity-ratios between lateral and septal wall, anterior and inferior wall, and basal and apical segments as dimensionless parameter for a comparison between species. Results Similar behavior in the global LV myocardial motion pattern was observed in all species, particularly for the radial and long-axis motion as can be seen in Figure 1. However, a markedly different rotational behavior
during early systole was found in mice, which exhibited clockwise rotation in all slice locations compared to counter-clockwise rotation in rabbits and humans (arrows in Figure 1). Regional analysis revealed significant differences in the velocity-ratio between lateral and septal radial and long-axis peak velocities between mice and rabbits (p
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