A Fluorescent Zn(II)-Coordination Polymer: Selective Detection of Nitrofurantoin and Prevention of Peri-Implantitis afte
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ORIGINAL ARTICLE
A Fluorescent Zn(II)-Coordination Polymer: Selective Detection of Nitrofurantoin and Prevention of Peri-Implantitis after Ultrafine-Grained Titanium Implant by Reducing Inflammatory Cytokines Release Mingda Liu 1 & Yanxia Chi 1 Received: 1 April 2020 / Accepted: 23 June 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract In the current research, a novel coordination polymer (CP) containing Zn(II) ions as nodes with the chemical formula of [Zn(IPT)2]n (1) has been produced via reaction of Zn(NO3)2·6H2O with 5-(3-(1H-imidazol-1-yl)phenyl)-1H-tetrazolate (HIPT), a heterotopic imidazole-tetrazole-bifunctional ligand. The as-prepared complex 1 has been charactered via single crystal X-ray diffraction, elemental analysis, powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA) and fourier transform infrared spectroscopy (FT-IR). Because of its outstanding luminescent performances and stability, the synthesized complex 1 is a kind of excellent material of luminescent sensor of nitrofurantoin (NFT) in the water. The value of Ksv for the complex 1 to NFT is about 1.4 × 104 M−1. For the treatment of the peri-implantitis with complex 1, the ELISA test was carried out to determine the levels of the inflammatory cytokines released into the gingival crevicular fluid. The results showed that the levels of the inflammatory cytokines could be significantly reduced by complex 1 treatment. In addition to this, the real time RT-PCR was also conducted, and the data suggested the signaling pathway of TLR-4-NF-κB activation was inhibited by complex 1. Keywords Coordination polymer . Zn-complex . Bifunctional ligand . Nitrofurantoin detection . Peri-implantitis
Introduction Peri-implantitis refers to the tissue inflammatory response caused by the invasion of tissues around the implant due to the invasion of pathogens such as bacteria [1]. It is also one of the main complications affecting the effectiveness of dental implants. Tumor necrosis factor-α and interleukin-1β are the major inflammatory cytokines released to periodontal tissue [2, 3]. The TNF-α and IL-1β content around the implant is about 2 to 3 folds of that around natural periodontal tissue. Thus, inhibiting the inflammatory response in the gingival tissue around the implant and reducing the releasing of the inflammatory cytokines released to periodontal tissue was important for the peri-implantitis treatment [4]. Coordination polymers (CPs) have been widely investigated because of their structural diversities, at the same time due * Yanxia Chi [email protected] 1
Jiamusi University, Jiamusi, Heilongjiang, China
to their application in gas separation and storage and catalysis [5–8]. Nevertheless, most of the carboxylic acid CPs materials have low thermal stability and they are easy to decompose when encountering water, which greatly limits their commercial or industrial applications [9–12]. Since water is everywhere in our living surroundings, if CPs are to be practically used, their water unstability must be ove
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