A Handbook of Transcription Factors

Transcription factors are - in the most common use of the term - proteins that possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes in proximity to the binding site. Transcription factors a

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SUBCELLULAR BIOCHEMISTRY SERIES EDITOR J. ROBIN HARRIS, University of Mainz, Mainz, Germany

ASSISTANT EDITOR P.J. QUINN, King’s College London, London, U.K. Recent Volumes in this Series Volume 33 Bacterial Invasion into Eukaryotic Cells Tobias A. Oelschlaeger and Jorg Hacker Volume 34 Fusion of Biological Membranes and Related Problems Edited by Herwig Hilderson and Stefan Fuller Volume 35 Enzyme-Catalyzed Electron and Radical Transfer Andreas Holzenburg and Nigel S. Scrutton Volume 36 Phospholipid Metabolism in Apoptosis Edited by Peter J. Quinn and Valerian E. Kagan Volume 37 Membrane Dynamics and Domains Edited by P.J. Quinn Volume 38 Alzheimer’s Disease: Cellular and Molecular Aspects of Amyloid beta Edited by R. Harris and F. Fahrenholz Volume 39 Biology of Inositols and Phosphoinositides Edited by A. Lahiri Majumder and B.B. Biswas Volume 40 Reviews and Protocols in DT40 Research Edited by Jean-Marie Buerstedde and Shunichi Takeda Volume 41 Chromatin and Disease Edited by Tapas K. Kundu and Dipak Dasgupta Volume 42 Inflammation in the Pathogenesis of Chronic Diseases Edited by Randall E. Harris Volume 43 Subcellular Proteomics Edited by Eric Bertrand and Michel Faupel Volume 44 Peroxiredoxin Systems Edited by Leopold Flohd J. Robin Harris Volume 45 Calcium Signalling and Disease Edited by Ernesto Carafoli and Marisa Brini Volume 46 Creatine and Creatine Kinase in Health and Disease Edited by Gajja S. Salomons and Markus Wyss Volume 47 Molecular Mechanisms of Parasite Invasion Edited by Barbara A. Burleigh and Dominique Soldati-Favre Volume 48 The Coronin Family of Proteins Edited by Christoph S. Clemen, Ludwig Eichinger and Vasily Rybakin Volume 49 Lipids in Health and Disease Edited by Peter J. Quinn and Xiaoyuan Wang Volume 50 Genome Stability and Human Diseases Edited by Heinz Peter Nasheuer Volume 51 Cholesterol Binding and Cholesterol Transport Proteins Edited by J. Robin Harris Volume 52 A Handbook of Transcription Factors Edited by T.R. Hughes For further volumes: http://www.springer.com/series/6515

T.R. Hughes Editor

A Handbook of Transcription Factors

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Editor T.R. Hughes University of Toronto Centre for Cellular and Biomolecular Research 160 College St. M5S 3E1 Toronto Canada [email protected]

ISSN 0306-0225 ISBN 978-90-481-9068-3 e-ISBN 978-90-481-9069-0 DOI 10.1007/978-90-481-9069-0 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2011926500 © Springer Science+Business Media B.V. 2011 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

INTERNATIONAL ADVISORY EDITORIAL BOARD R. BITTMAN, Queens College,