Role of Transcription Factors in Gastrointestinal Malignancies
This book illustrates the importance of transcription factors in gastrointestinal cancer progression and metastasis with regard to understanding the mechanism and target definition in drug discovery. Further, it describes the complex issues associated wit
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Role of Transcription Factors in Gastrointestinal Malignancies
Role of Transcription Factors in Gastrointestinal Malignancies
Ganji Purnachandra Nagaraju Pallaval Veera Bramhachari Editors
Role of Transcription Factors in Gastrointestinal Malignancies
Editors Ganji Purnachandra Nagaraju Department of Hematology and Medical Oncology Emory University Atlanta, GA, USA
Pallaval Veera Bramhachari Department of Biotechnology Krishna University Machilipatnam, Andhra Pradesh, India
ISBN 978-981-10-6727-3 ISBN 978-981-10-6728-0 (eBook) https://doi.org/10.1007/978-981-10-6728-0 Library of Congress Control Number: 2018930987 © Springer Nature Singapore Pte Ltd. 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Contents
1 Transcription Factors in Gastrointestinal Malignancies���������������������� 1 Pallaval Veera Bramhachari and Ganji Purnachandra Nagaraju 2 YY1 and KLF4: Their Role in Gastrointestinal Malignancies������������ 3 Himanshu Tillu and Ganji Purnachandra Nagaraju 3 AP-1: Its Role in Gastrointestinal Malignancies���������������������������������� 17 P. S. Sushma, P. UdayKumar, and Aliya Sheik 4 Overview of Transcription Factors in Esophagus Cancer ������������������ 31 Pallaval Veera Bramhachari, A. M. V. N. Prathyusha, and D. Rama Sekhara Reddy 5 NF-κB Role and Potential Drug Targets in Gastrointestinal Cancer���������������������������������������������������������������������� 43 Prudhvi Lal Bhukya, Rongala Laxmivandana and Gopinath Meenakshi Sundaram 6 HIF-1α: Its Role in Metastasis of Oesophageal Malignancy �������������� 71 A. M. V. N. Prathyusha, Godi Raghu, and Pallaval Veera Bramhachari
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