A high-fat high-energy diet influences hepatic CYP3A expression and activity in low-birth-weight developing female rats
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A high-fat high-energy diet influences hepatic CYP3A expression and activity in low-birth-weight developing female rats Shao-Qing Ni, Yin Lou, Xiu-Min Wang, Zheng Shen, Jue Wang, Zheng-Yan Zhao, Su Zeng Hangzhou, China
Methods: Pregnant rats were divided into nourished and undernourished groups. The offspring of the nourished rats were defined as the normal-birth-weight (NBW) group, and those of undernourished rats were defined as the low-birth-weight (LBW) group. According to their birth weights and diets, the rats were subdivided into the following four groups: NBW-normal diet (NN) group; NBW-HFHE (NH) group; LBW-normal diet (LN) group; and LBW-HFHE (LH) group. Liver samples were isolated on days 3, 7, 14, 21, 28, 56 and 84 after birth. Results: The CYP3A1 mRNA levels in the LH group on days 3, 56 and 84 were significantly higher than those of the NN group (P
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