Vascular damage in obese female rats with hypoestrogenism
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ORIGINAL PAPER
Vascular damage in obese female rats with hypoestrogenism Luis Angel Lima-Mendoza & Juventino Colado-Velázquez III & Patrick Mailloux-Salinas & Josué V. Espinosa-Juárez & Norma L. Gómez-Viquez & Tzindilu Molina-Muñoz & Fengyang Huang & Guadalupe Bravo
Received: 5 September 2012 / Accepted: 12 August 2013 / Published online: 31 August 2013 # University of Navarra 2013
Abstract Increase in body weight and adiposity has deleterious consequences on health. The aim of this study was to compare morphological and metabolic changes in the arterial vessels of Wistar rats with conditions of obesity, hypoestrogenism, and hypoestrogenism plus obesity. Ovariectomized rats (hypoestrogenic condition) received 30 % sugar in drinking water plus standard diet during 10 weeks. The hypoestrogenic-obese (HE-OB) group presented increase in weight, blood pressure, hypertriglyceridemia, and hyperglycemia compared with other groups. The morphological study in aortic vessels from HE showed damage in endothelial smooth muscle tissue compared with the other groups. Adipose cells volume in HE-OB (59.33±2.38 μ3×105) and obese (OB) (54.95±1.36 μ3×105) groups were significantly larger than control group (36.38±0.98 μ3×105). In the HE group adipocyte hyperplasia was observed, while in OB group adipocyte hypertrophy and hyperplasia was L. A. Lima-Mendoza : J. Colado-Velázquez III : P. Mailloux-Salinas : J. V. Espinosa-Juárez : N. L. Gómez-Viquez : T. Molina-Muñoz : G. Bravo Pharmacobiology Department, Cinvestav-IPN, Sede Sur, Mexico, Mexico F. Huang Department of Pharmacology and Toxicology, Hospital Infantil de México Federico Gómez, Mexico, Mexico G. Bravo (*) Departamento Farmacobiología, Cinvestav-IPN, Calz. de los Tenorios 235, Col. Granjas Coapa, 14330 Mexico, Mexico e-mail: [email protected]
shown. The vascular reactivity in HE-OB and OB groups presented decrease in the relaxation to acetylcholine compared with control conditions (p
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