A meta-analysis of fractional CO 2 laser combined with PRP in the treatment of acne scar
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REVIEW ARTICLE
A meta-analysis of fractional CO2 laser combined with PRP in the treatment of acne scar Nan Wu 1 & Hongyan Sun 2 & Qian Sun 1 & Lele Cong 1 & Chenlu Liu 2 & Yang Zheng 1 & Lei Ma 2 & Xianling Cong 1 Received: 5 February 2020 / Accepted: 22 July 2020 # Springer-Verlag London Ltd., part of Springer Nature 2020
Abstract This study aimed to analyze the effectiveness and safety of ablative fractional carbon dioxide laser systems (CO2 AFL) combined with autologous platelet-rich plasma (PRP) in the treatment of acne scars through the retrieval and collection of related literature to further guide the treatment of acne scars. We searched Web of Science, PubMed, Embase, Wanfang Data, Chinese National Knowledge Infrastructure, and VIP Database. All randomized and nonrandomized controlled trials on CO2 AFL combined with PRP in the treatment of acne scars were included, and Revman5.3 systematic review software was used in the meta-analysis. Nine studies were included in this meta-analysis. The data analysis results showed that the CO2 AFL combined with PRP treatment group showed significantly better results than the pure CO2 AFL control group in terms of clinical improvement score, clinical improvement rate, patient satisfaction, and crusting period. The results of this meta-analysis showed that CO2 AFL combined with PRP in the treatment of acne scars is more effective and safer than CO2 AFL alone. Keywords Acne scar . Ablative fractional carbon dioxide laser systems . Autologous platelet-rich plasma . Meta-analysis
Introduction Acne is a common chronic inflammatory disease of the hair follicles and sebaceous glands. It often develops in adolescent men and women. It affects 80% of adolescents to a certain extent. It develops in all age groups and has a certain family inheritance [1–6]. Acne is caused by a variety of factors, mainly related to androgens, increased sebum secretion, abnormal keratinization of the hair follicle and sebaceous ducts, Propionibacterium acnes proliferation, and inflammatory responses to lymphocytes, macrophages, and neutrophils [7, 8]. Acne scars are a common healing outcome of acne. Of patients with acne, 50% have clinically significant acne scars
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10103-020-03105-z) contains supplementary material, which is available to authorized users. * Xianling Cong [email protected] 1
Department of Dermatology, China-Japan Union Hospital of Jilin University, Xiantai Road 126, Changchun 130033, Jilin, People’s Republic of China
2
Tissue Bank, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China
after healing. They can be divided into atrophic acne, proliferative acne, and keloid. Atrophic scars are more common [9–11]. Acne skin lesions often develop on the cheeks and forehead, and acne scars often develop in highly visible areas such as the face, which affects not only the patient’s beauty but also mental health, social relationships, and personal happiness
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