A new instrument for measuring anticoagulation-related quality of life: development and preliminary validation
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A new instrument for measuring anticoagulation-related quality of life: development and preliminary validation Greg Samsa*1,3, David B Matchar2,4, Rowena J Dolor2,4, Ingela Wiklund5, Ewa Hedner5, Gail Wygant5, Ole Hauch5, Cheryl Beadle Marple5 and Roger Edwards6,7 Address: 1Department of Biometry and Bioinformatics, Duke University Medical Center, Wachovia Plaza, Suite 220, 2200 West Main Street, Durham NC 27705, USA, 2Department of Medicine, Duke University Medical Center, Durham NC, USA, 3Center for Clinical Health Policy Research, Duke University Medical Center, Durham NC, USA, 4Department of Veterans Affairs Medical Center, Durham NC, USA, 5AstraZeneca Pharmaceuticals, Stockholm, Sweden, 6Health Services Consulting Corporation, Cambridge MA, USA and 7TIAX Inc, Cambridge MA, USA Email: Greg Samsa* - [email protected]; David B Matchar - [email protected]; Rowena J Dolor - [email protected]; Ingela Wiklund - [email protected]; Ewa Hedner - [email protected]; Gail Wygant - [email protected]; Ole Hauch - [email protected]; Cheryl Beadle Marple - [email protected]; Roger Edwards - [email protected] * Corresponding author
Published: 06 May 2004 Health and Quality of Life Outcomes 2004, 2:22
Received: 15 March 2004 Accepted: 06 May 2004
This article is available from: http://www.hqlo.com/content/2/1/22 © 2004 Samsa et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
Abstract Background: Anticoagulation can reduce quality of life, and different models of anticoagulation management might have different impacts on satisfaction with this component of medical care. Yet, to our knowledge, there are no scales measuring quality of life and satisfaction with anticoagulation that can be generalized across different models of anticoagulation management. We describe the development and preliminary validation of such an instrument – the Duke Anticoagulation Satisfaction Scale (DASS). Methods: The DASS is a 25-item scale addressing the (a) negative impacts of anticoagulation (limitations, hassles and burdens); and (b) positive impacts of anticoagulation (confidence, reassurance, satisfaction). Each item has 7 possible responses. The DASS was administered to 262 patients currently receiving oral anticoagulation. Scales measuring generic quality of life, satisfaction with medical care, and tendency to provide socially desirable responses were also administered. Statistical analysis included assessment of item variability, internal consistency (Cronbach's alpha), scale structure (factor analysis), and correlations between the DASS and demographic variables, clinical characteristics, and scores on the above scales. A follow-up study of 105 additional patients assessed test-retest reliability. Results: 220 subjects answered all items. Ceiling and floor effects we
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