A new technique for ureteral reconstruction using lingual mucosa grafts in a beagle model
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UROLOGY - ORIGINAL PAPER
A new technique for ureteral reconstruction using lingual mucosa grafts in a beagle model Yujie Xu1,2 · Lin Sun1 · Qiufeng Pan1 · Xiaoliang Hua1 · Bing Li1 Received: 21 June 2020 / Accepted: 17 August 2020 © Springer Nature B.V. 2020
Abstract Purpose To investigate the feasibility of ureteral reconstruction using lingual mucosa graft (LMG) and evaluate the histological changes of the engrafted LMG in beagles. Methods Twelve male beagle dogs were randomly divided into groups A, B and C (n = 4). A ventral ureteral defect was created by excising half of the ureteral wall. The length of the defect was 3 cm, 6 cm, and 10 cm in groups A, B, and C, respectively. The LMGs were harvested and employed to repair the ureteral defects in onlay fashion. Two dogs per group were sacrificed after 6 months, with additional two dogs per group sacrificed after 12 months. Intravenous urography (IVU) and macroscopic examination were performed to evaluate renal function and ureteral patency. Histological changes in the engrafted LMGs during the tissue incorporation process were assessed by histological analysis. Results There were no postoperative complications. Only one dog in group C developed a mild stricture near the proximal anastomosis. In the remaining 11 animals, IVU showed normal renal function and a wide ureteral caliber without stricture or fistula. The diameter of the LMG-reconstructed ureter was greater than that of the proximal and distal ureter (each p value
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